TY - JOUR
T1 - An Old Dog Has a New Trick
T2 - Somatic Exonic Deletions in RUNX1 Are Frequent in AML
AU - Chakraborty, Joyeeta
AU - Stengel, Kristy R.
N1 - Publisher Copyright:
© 2023 American Association for Cancer Research.
PY - 2023
Y1 - 2023
N2 - Somatic loss-of-function RUNX1 mutations in acute myeloid leukemia (AML) include missense, nonsense, and frameshift mutations, whereas germline RUNX1 variants in RUNX1-FPDMM also include large exonic deletions. Alternative variant detection approaches revealed that large exonic deletions in RUNX1 are also common in sporadic AML, which has implications for patient stratification and therapeutic decision-making. See related article by Eriksson et al., p. 2826.
AB - Somatic loss-of-function RUNX1 mutations in acute myeloid leukemia (AML) include missense, nonsense, and frameshift mutations, whereas germline RUNX1 variants in RUNX1-FPDMM also include large exonic deletions. Alternative variant detection approaches revealed that large exonic deletions in RUNX1 are also common in sporadic AML, which has implications for patient stratification and therapeutic decision-making. See related article by Eriksson et al., p. 2826.
UR - http://www.scopus.com/inward/record.url?scp=85166393773&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85166393773&partnerID=8YFLogxK
U2 - 10.1158/1078-0432.CCR-23-1065
DO - 10.1158/1078-0432.CCR-23-1065
M3 - Article
C2 - 37249497
AN - SCOPUS:85166393773
SN - 1078-0432
VL - 29
SP - 2742
EP - 2744
JO - Clinical Cancer Research
JF - Clinical Cancer Research
IS - 15
ER -