TY - JOUR
T1 - An official American Thoracic Society Workshop Report
T2 - Chemical inhalational disasters biology of lung injury, development of novel therapeutics, and medical preparedness
AU - Summerhill, Eleanor M.
AU - Hoyle, Gary W.
AU - Jordt, Sven Eric
AU - Jugg, Bronwen J.
AU - Martin, James G.
AU - Matalon, Sadis
AU - Patterson, Steven E.
AU - Prezant, David J.
AU - Sciuto, Alfred M.
AU - Svendsen, Erik R.
AU - White, Carl W.
AU - Veress, Livia A.
N1 - Publisher Copyright:
© 2017 by the American Thoracic Society.
PY - 2017/6
Y1 - 2017/6
N2 - This report is based on the proceedings from the Inhalational Lung InjuryWorkshop jointly sponsored by the American Thoracic Society (ATS) and the National Institutes of Health (NIH) Countermeasures Against Chemical Threats (CounterACT) program on May 21, 2013, in Philadelphia, Pennsylvania. The CounterACT program facilitates research leading to the development of new and improved medical countermeasures for chemical threat agents. The workshop was initiated by the Terrorism and Inhalational Disasters Section of the Environmental,Occupational, and Population Health Assembly of the ATS. Participants included both domestic and international experts in the field, as well as representatives from U.S. governmental funding agencies. The meeting objectiveswere to (1) provide a forumto review the evidence supporting current standard medical therapies, (2) present updates on our understanding of the epidemiology and underlying pathophysiology of inhalational lung injuries, (3) discuss innovative investigative approaches to further delineating mechanisms of lung injury and identifying new specific therapeutic targets, (4) present promising novel medical countermeasures, (5) facilitate collaborative research efforts, and (6) identify challenges and future directions in the ongoing development, manufacture, and distribution of effective and specific medical countermeasures. Specific inhalational toxins discussed included irritants/pulmonary toxicants (chlorine gas, bromine, and phosgene), vesicants (sulfur mustard), chemical asphyxiants (cyanide), particulates (World Trade Center dust), and respirable nerve agents.
AB - This report is based on the proceedings from the Inhalational Lung InjuryWorkshop jointly sponsored by the American Thoracic Society (ATS) and the National Institutes of Health (NIH) Countermeasures Against Chemical Threats (CounterACT) program on May 21, 2013, in Philadelphia, Pennsylvania. The CounterACT program facilitates research leading to the development of new and improved medical countermeasures for chemical threat agents. The workshop was initiated by the Terrorism and Inhalational Disasters Section of the Environmental,Occupational, and Population Health Assembly of the ATS. Participants included both domestic and international experts in the field, as well as representatives from U.S. governmental funding agencies. The meeting objectiveswere to (1) provide a forumto review the evidence supporting current standard medical therapies, (2) present updates on our understanding of the epidemiology and underlying pathophysiology of inhalational lung injuries, (3) discuss innovative investigative approaches to further delineating mechanisms of lung injury and identifying new specific therapeutic targets, (4) present promising novel medical countermeasures, (5) facilitate collaborative research efforts, and (6) identify challenges and future directions in the ongoing development, manufacture, and distribution of effective and specific medical countermeasures. Specific inhalational toxins discussed included irritants/pulmonary toxicants (chlorine gas, bromine, and phosgene), vesicants (sulfur mustard), chemical asphyxiants (cyanide), particulates (World Trade Center dust), and respirable nerve agents.
UR - http://www.scopus.com/inward/record.url?scp=85020210244&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85020210244&partnerID=8YFLogxK
U2 - 10.1513/AnnalsATS.201704-297WS
DO - 10.1513/AnnalsATS.201704-297WS
M3 - Article
C2 - 28418689
AN - SCOPUS:85020210244
SN - 2325-6621
VL - 14
SP - 1060
EP - 1072
JO - Annals of the American Thoracic Society
JF - Annals of the American Thoracic Society
IS - 6
ER -