TY - JOUR
T1 - An initial application of transesophageal Doppler echocardiography in experimental small animal models
AU - Gao, Zhaohui
AU - Li, Jianhua
AU - Kehoe, Valerie
AU - Davidson, William R.
AU - Sinoway, Lawrence
AU - Pu, Min
N1 - Funding Information:
Dr Pu is, in part, supported by the grant-in-aid from the American Society of Echocardiography and the Scientists Development Grant from the American Heart Association. Dr Sinoway is, in part, supported by National Institutes of Health R01 HL0060800 grant.
PY - 2005/6
Y1 - 2005/6
N2 - This study examined whether an intracardiac echocardiography catheter could be used for transesophageal echocardiography (TEE) examinations in normal rats, and intraoperative TEE in small animal models of disease. The study used 30 Sprague-Dawley normal rats, 10 rats undergoing coronary artery ligation, and 10 rats with experimentally induced mitral regurgitation. The rats were anesthetized with isoflurane and intubated. An intracardiac echocardiographic catheter was inserted into the esophagus. M-mode, 2-dimensional, and Doppler studies were performed in multiple views. TEE probe insertions were successful in all animals. Intraoperative TEE was safely performed in the rat models of myocardial infarction or mitral regurgitation. Mitral regurgitation was well assessed using color Doppler and pulmonary venous flow. This study demonstrates that TEE (including intraoperative TEE) can be safely performed in rats using an intracardiac echocardiographic catheter. It provides a new approach to the assessment of cardiac function and valvular regurgitation in small animals.
AB - This study examined whether an intracardiac echocardiography catheter could be used for transesophageal echocardiography (TEE) examinations in normal rats, and intraoperative TEE in small animal models of disease. The study used 30 Sprague-Dawley normal rats, 10 rats undergoing coronary artery ligation, and 10 rats with experimentally induced mitral regurgitation. The rats were anesthetized with isoflurane and intubated. An intracardiac echocardiographic catheter was inserted into the esophagus. M-mode, 2-dimensional, and Doppler studies were performed in multiple views. TEE probe insertions were successful in all animals. Intraoperative TEE was safely performed in the rat models of myocardial infarction or mitral regurgitation. Mitral regurgitation was well assessed using color Doppler and pulmonary venous flow. This study demonstrates that TEE (including intraoperative TEE) can be safely performed in rats using an intracardiac echocardiographic catheter. It provides a new approach to the assessment of cardiac function and valvular regurgitation in small animals.
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U2 - 10.1016/j.echo.2004.08.032
DO - 10.1016/j.echo.2004.08.032
M3 - Article
C2 - 15947763
AN - SCOPUS:20444377251
SN - 0894-7317
VL - 18
SP - 626
EP - 631
JO - Journal of the American Society of Echocardiography
JF - Journal of the American Society of Echocardiography
IS - 6
ER -