An antimicrobial activity of cytolytic T cells mediated by granulysin

Steffen Stenger; Dennis A. Hanson; Rachel Teitelbaum; Puneet Dewan; Kayvan R. Niazi; Christopher J. Froelich; Tomas Ganz; Sybille Thoma-Uszynski; Agustín Melián; Christian Bogdan; Steven A. Porcelli; Barry R. Bloom; Alan M. Krensky; Robert L. Modlin

doi:10.1126/science.282.5386.121

An antimicrobial activity of cytolytic T cells mediated by granulysin

Steffen Stenger, Dennis A. Hanson, Rachel Teitelbaum, Puneet Dewan, Kayvan R. Niazi, Christopher J. Froelich, Tomas Ganz, Sybille Thoma-Uszynski, Agustín Melián, Christian Bogdan, Steven A. Porcelli, Barry R. Bloom, Alan M. Krensky, Robert L. Modlin

Research output: Contribution to journal › Article › peer-review

913 Scopus citations

Abstract

Cytolytic T lymphocytes (CTLs) kill intracellular pathogens by a granule-dependent mechanism. Granulysin, a protein found in granules of CTLs, reduced the viability of a broad spectrum of pathogenic bacteria, fungi, and parasites in vitro. Granulysin directly killed extracellular Mycobacterium tuberculosis, altering the membrane integrity of the bacillus, and, in combination with perforin, decreased the viability of intracellular M. tuberculosis. The ability of CTLs to kill intracellular M. tuberculosis was dependent on the presence of granulysin in cytotoxic granules, defining a mechanism by which T cells directly contribute to immunity against intracellular pathogens.

Original language	English (US)
Pages (from-to)	121-125
Number of pages	5
Journal	Science
Volume	282
Issue number	5386
DOIs	https://doi.org/10.1126/science.282.5386.121
State	Published - Oct 2 1998
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1126/science.282.5386.121

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title = "An antimicrobial activity of cytolytic T cells mediated by granulysin",

abstract = "Cytolytic T lymphocytes (CTLs) kill intracellular pathogens by a granule-dependent mechanism. Granulysin, a protein found in granules of CTLs, reduced the viability of a broad spectrum of pathogenic bacteria, fungi, and parasites in vitro. Granulysin directly killed extracellular Mycobacterium tuberculosis, altering the membrane integrity of the bacillus, and, in combination with perforin, decreased the viability of intracellular M. tuberculosis. The ability of CTLs to kill intracellular M. tuberculosis was dependent on the presence of granulysin in cytotoxic granules, defining a mechanism by which T cells directly contribute to immunity against intracellular pathogens.",

author = "Steffen Stenger and Hanson, {Dennis A.} and Rachel Teitelbaum and Puneet Dewan and Niazi, {Kayvan R.} and Froelich, {Christopher J.} and Tomas Ganz and Sybille Thoma-Uszynski and Agust{\'i}n Meli{\'a}n and Christian Bogdan and Porcelli, {Steven A.} and Bloom, {Barry R.} and Krensky, {Alan M.} and Modlin, {Robert L.}",

year = "1998",

month = oct,

day = "2",

doi = "10.1126/science.282.5386.121",

language = "English (US)",

volume = "282",

pages = "121--125",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

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TY - JOUR

T1 - An antimicrobial activity of cytolytic T cells mediated by granulysin

AU - Stenger, Steffen

AU - Hanson, Dennis A.

AU - Teitelbaum, Rachel

AU - Dewan, Puneet

AU - Niazi, Kayvan R.

AU - Froelich, Christopher J.

AU - Ganz, Tomas

AU - Thoma-Uszynski, Sybille

AU - Melián, Agustín

AU - Bogdan, Christian

AU - Porcelli, Steven A.

AU - Bloom, Barry R.

AU - Krensky, Alan M.

AU - Modlin, Robert L.

PY - 1998/10/2

Y1 - 1998/10/2

N2 - Cytolytic T lymphocytes (CTLs) kill intracellular pathogens by a granule-dependent mechanism. Granulysin, a protein found in granules of CTLs, reduced the viability of a broad spectrum of pathogenic bacteria, fungi, and parasites in vitro. Granulysin directly killed extracellular Mycobacterium tuberculosis, altering the membrane integrity of the bacillus, and, in combination with perforin, decreased the viability of intracellular M. tuberculosis. The ability of CTLs to kill intracellular M. tuberculosis was dependent on the presence of granulysin in cytotoxic granules, defining a mechanism by which T cells directly contribute to immunity against intracellular pathogens.

AB - Cytolytic T lymphocytes (CTLs) kill intracellular pathogens by a granule-dependent mechanism. Granulysin, a protein found in granules of CTLs, reduced the viability of a broad spectrum of pathogenic bacteria, fungi, and parasites in vitro. Granulysin directly killed extracellular Mycobacterium tuberculosis, altering the membrane integrity of the bacillus, and, in combination with perforin, decreased the viability of intracellular M. tuberculosis. The ability of CTLs to kill intracellular M. tuberculosis was dependent on the presence of granulysin in cytotoxic granules, defining a mechanism by which T cells directly contribute to immunity against intracellular pathogens.

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VL - 282

SP - 121

EP - 125

JO - Science

JF - Science

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ER -

An antimicrobial activity of cytolytic T cells mediated by granulysin

Abstract

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