TY - JOUR
T1 - An analysis of the determinants of hepatic allograft rejection using stepwise logistic regression
AU - Sankary, Howard
AU - Foster, Preston
AU - Hart, Marquis
AU - Ashmann, Marilyn
AU - Schwartz, Daniel
AU - Williams, James W.
PY - 1989/1
Y1 - 1989/1
N2 - Hepatic allograft rejection is currently diagnosed usiqg both histologic and clinical criteria. The purpose of this study is to extract data from the allograft biopsy, which can establish the diagnosis of rejection with more precision. A total of 566 allograft biopsies were examined in 56 patients following orthotopic liver transplantation, and 35 variables were examined. Using stepwise logistic regression, only six of these variables affected the diagnosis of rejection. These were portal tract spill1 over, portal tract eosinophilia, portal vein endothelialitis, portal tract neutrophilia, central vein endothelialitis, and cholestasis. Coefficients of these variables were determined, and could be used to calculate the probability of rejection for a given biopsy. Using this model the probability of having rejection can be calculated using histologic data alone.
AB - Hepatic allograft rejection is currently diagnosed usiqg both histologic and clinical criteria. The purpose of this study is to extract data from the allograft biopsy, which can establish the diagnosis of rejection with more precision. A total of 566 allograft biopsies were examined in 56 patients following orthotopic liver transplantation, and 35 variables were examined. Using stepwise logistic regression, only six of these variables affected the diagnosis of rejection. These were portal tract spill1 over, portal tract eosinophilia, portal vein endothelialitis, portal tract neutrophilia, central vein endothelialitis, and cholestasis. Coefficients of these variables were determined, and could be used to calculate the probability of rejection for a given biopsy. Using this model the probability of having rejection can be calculated using histologic data alone.
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U2 - 10.1097/00007890-198901000-00017
DO - 10.1097/00007890-198901000-00017
M3 - Article
C2 - 2643235
AN - SCOPUS:0024570230
SN - 0041-1337
VL - 47
SP - 74
EP - 77
JO - Transplantation
JF - Transplantation
IS - 1
ER -