Abstract
It is possible to accelerate amyloid formation in both the Senescence Accelerated Mouse, where ApoAIIC is the precursor, and in murine Amyloid A (AA) by the injection of preformed fibrils in the former and amyloid enhancing factor, which appears to consist of AA fibril fragments, in the latter. These two observations have raised the question of whether murine amyloids, like scrapie, are infectious. Injection of preformed fibrils into mice transgenic for many copies of the human wild-type transthyretin gene do not result in acceleration or enhancement of the process of deposition or the conversion of non-Congophilic deposits to fibrils.
Original language | English (US) |
---|---|
Pages (from-to) | 21-26 |
Number of pages | 6 |
Journal | Amyloid |
Volume | 11 |
Issue number | 1 |
DOIs | |
State | Published - Mar 2004 |
Externally published | Yes |
Keywords
- Amyloidogenesis
- Seeding
- Transgenic animals
- Transthyretin
ASJC Scopus subject areas
- Internal Medicine