Amplified C(λ) and c-abl genes are on the same marker chromosome in K562 leukemia cells

J. R. Selden; B. S. Emanuel; E. Wang; L. Cannizzaro; A. Palumbo; J. Erikson; P. C. Nowell; G. Rovera; C. M. Croce

doi:10.1073/pnas.80.23.7289

Amplified C(λ) and c-abl genes are on the same marker chromosome in K562 leukemia cells

J. R. Selden, B. S. Emanuel, E. Wang, L. Cannizzaro, A. Palumbo, J. Erikson, P. C. Nowell, G. Rovera, C. M. Croce

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Abstract

The human leukemia cell line K562, derived from a patient with Philadelphia chromosome-positive chronic myelogenous leukemia, contains amplified c-abl oncogenes and unrearranged C(λ) genes. Using in situ hybridization techniques, we have determined that the amplified c-abl and C(λ) DNA sequences of K562 cells are both located on the same abnormal acrocentric marker chromosome, which may represent an altered Philadelphia chromosome.

Original language	English (US)
Pages (from-to)	7289-7292
Number of pages	4
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	80
Issue number	23 I
DOIs	https://doi.org/10.1073/pnas.80.23.7289
State	Published - 1983
Externally published	Yes

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title = "Amplified C(λ) and c-abl genes are on the same marker chromosome in K562 leukemia cells",

abstract = "The human leukemia cell line K562, derived from a patient with Philadelphia chromosome-positive chronic myelogenous leukemia, contains amplified c-abl oncogenes and unrearranged C(λ) genes. Using in situ hybridization techniques, we have determined that the amplified c-abl and C(λ) DNA sequences of K562 cells are both located on the same abnormal acrocentric marker chromosome, which may represent an altered Philadelphia chromosome.",

author = "Selden, {J. R.} and Emanuel, {B. S.} and E. Wang and L. Cannizzaro and A. Palumbo and J. Erikson and Nowell, {P. C.} and G. Rovera and Croce, {C. M.}",

year = "1983",

doi = "10.1073/pnas.80.23.7289",

language = "English (US)",

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pages = "7289--7292",

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T1 - Amplified C(λ) and c-abl genes are on the same marker chromosome in K562 leukemia cells

AU - Selden, J. R.

AU - Emanuel, B. S.

AU - Wang, E.

AU - Cannizzaro, L.

AU - Palumbo, A.

AU - Erikson, J.

AU - Nowell, P. C.

AU - Rovera, G.

AU - Croce, C. M.

PY - 1983

Y1 - 1983

N2 - The human leukemia cell line K562, derived from a patient with Philadelphia chromosome-positive chronic myelogenous leukemia, contains amplified c-abl oncogenes and unrearranged C(λ) genes. Using in situ hybridization techniques, we have determined that the amplified c-abl and C(λ) DNA sequences of K562 cells are both located on the same abnormal acrocentric marker chromosome, which may represent an altered Philadelphia chromosome.

AB - The human leukemia cell line K562, derived from a patient with Philadelphia chromosome-positive chronic myelogenous leukemia, contains amplified c-abl oncogenes and unrearranged C(λ) genes. Using in situ hybridization techniques, we have determined that the amplified c-abl and C(λ) DNA sequences of K562 cells are both located on the same abnormal acrocentric marker chromosome, which may represent an altered Philadelphia chromosome.

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U2 - 10.1073/pnas.80.23.7289

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SN - 0027-8424

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EP - 7292

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 23 I

ER -

Amplified C(λ) and c-abl genes are on the same marker chromosome in K562 leukemia cells

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