The human leukemia cell line K562, derived from a patient with Philadelphia chromosome-positive chronic myelogenous leukemia, contains amplified c-abl oncogenes and unrearranged C(λ) genes. Using in situ hybridization techniques, we have determined that the amplified c-abl and C(λ) DNA sequences of K562 cells are both located on the same abnormal acrocentric marker chromosome, which may represent an altered Philadelphia chromosome.
|Number of pages
|Proceedings of the National Academy of Sciences of the United States of America
|Published - 1983
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