Ameloblastoma with adenoid features: Case report with cyto-histopathologic correlation and molecular findings

Sebastian A. Jofre, Maxwell Roth, Arash H. Lahouti, Adam Gersten, Abul Kalam Azad, Robert D. Kelsch, Saeed Asiry, Yitzchak Goldstein, Rizwan Naeem, Rema Rao

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Ameloblastomas are benign but locally aggressive odontogenic tumors that commonly present as expansile lesions in the tooth-bearing areas. Fine-needle aspiration (FNA) biopsies of ameloblastomas are rare in clinical practice, and only a handful of case reports and series have described their cytologic features. We present the case of a 70-year-old woman with a large and disfiguring maxillary sinus soft tissue mass sampled via transcutaneous FNA. Aspirate smears were composed of small clusters of cohesive and monotonous basaloid cells. The accompanying cellblock showed similar clusters of basaloid cells in gland-like, or “adenoid,” configurations, eliciting a differential diagnosis that included sinonasal and salivary gland neoplasms. Excisional surgery material was consistent with ameloblastoma with adenoid morphology. Next-generation sequencing (NGS) analysis demonstrated FGFR2 and SMO pathogenic variants. This case exemplifies several uncommonly described features of ameloblastomas in cytology, including cyto-histologic correlation, adenoid morphology, and NGS findings. Awareness of the cytologic features of this neoplasm are important for cytopathologists confronted with maxillary sinus lesions.

Original languageEnglish (US)
Pages (from-to)E140-E145
JournalDiagnostic Cytopathology
Issue number6
StatePublished - Jun 2022


  • FGFR2
  • ameloblastoma
  • cytopathology
  • head and neck
  • histopathology

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology


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