TY - JOUR
T1 - Amelioration of experimental glomerulonephritis by dietary protein restriction
AU - Neugarten, J.
AU - Feiner, H. D.
AU - Schacht, R. G.
AU - Baldwin, D. S.
N1 - Funding Information:
Acknowledgments This study was presented in abstract form at the national meeting of the American Society for Clinical Investigation, Washington, D.C., May, 1982, and was supported by the Veterans Administration and grant AM-218l7 from the United States Public Health Service.
PY - 1983
Y1 - 1983
N2 - We have examined the effects of various levels of dietary protein intake on the course of nephrotic serum nephritis in the rat by feeding low (4.6% casein), standard (23% casein), and high (57.5% casein) protein diets which were identical in calorie, mineral, and electrolyte content. Nephritic rats on a high protein diet mainfested heavy proteinuremia, hypoalbuminia, hypercholesterolemia, azotemia, and elevated serum creatinine levels. In those subjected to dietary protein restriction, proteinuria remitted and azotemia did not develop. While mesangial widening, interstitial abnormalities, and segmental proliferation and sclerosis of glomeruli occurred regularly in nephritic rats fed high protein diets, histologic abnormalities were virtually absent in those on low protein intake. Animals on a standard protein intake manifested histologic and clinical features intermediate in severity. We conclude that the renal functional and histologic consequences of nephrotoxic serum nephritis can be averted by dietary protein restriction.
AB - We have examined the effects of various levels of dietary protein intake on the course of nephrotic serum nephritis in the rat by feeding low (4.6% casein), standard (23% casein), and high (57.5% casein) protein diets which were identical in calorie, mineral, and electrolyte content. Nephritic rats on a high protein diet mainfested heavy proteinuremia, hypoalbuminia, hypercholesterolemia, azotemia, and elevated serum creatinine levels. In those subjected to dietary protein restriction, proteinuria remitted and azotemia did not develop. While mesangial widening, interstitial abnormalities, and segmental proliferation and sclerosis of glomeruli occurred regularly in nephritic rats fed high protein diets, histologic abnormalities were virtually absent in those on low protein intake. Animals on a standard protein intake manifested histologic and clinical features intermediate in severity. We conclude that the renal functional and histologic consequences of nephrotoxic serum nephritis can be averted by dietary protein restriction.
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U2 - 10.1038/ki.1983.199
DO - 10.1038/ki.1983.199
M3 - Article
C2 - 6663981
AN - SCOPUS:0021044883
SN - 0085-2538
VL - 24
SP - 595
EP - 601
JO - Kidney international
JF - Kidney international
IS - 5
ER -