Alzheimer's disease: A healthcare burden of epidemic proportion

T. S. Dharmarajan, Srinivas G. Gunturu

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Alzheimer's disease is the most common cause of dementia and increases in prevalence exponentially with age, with trends in the United States likely to worsen in ensuing decades. The pathology in Alzheimer's disease is characterized by an increase in extracellular amyloid plaques and intraneural neurofibrillary tangles, with neuronal destruction in several areas of the brain, and biochemically by a deficiency in acetylcholine; clinical manifestations include progressive loss of memory, change in personality, and behavioral disturbances. Pharmacotherapy includes the use of cholinesterase inhibitors and memantine; addressing the many behavioral manifestations of the disease, especially in advanced stages, imposes tremendous burden to caregivers and healthcare resources.

Original languageEnglish (US)
Pages (from-to)39-47
Number of pages9
JournalAmerican Health and Drug Benefits
Issue number1
StatePublished - 2009

ASJC Scopus subject areas

  • Health Policy
  • Strategy and Management


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