Altered immune function in autism

Gina Delgiudice-Asch, Eric Hollander

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


Recent studies of the pathogenesis of autism have suggested that this disorder may have an autoimmune basis in some patients. Observations have been made regarding cellular and humoral immune dysfunction, abnormalities associated with the complement system and major histocompatibility complex gene expression, differences in soluble mediators of the immune response, and the presence of antibrain and antimyelin autoantibodies. In this article, we review these experimental and clinical observations, and examine preliminary efforts using immunomodulatory therapies to treat autism.

Original languageEnglish (US)
Pages (from-to)61-68
Number of pages8
JournalCNS spectrums
Issue number5
StatePublished - 1997
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health


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