Aging: One thing leads to another

Marion Schmidt; Brian K. Kennedy

doi:10.1016/j.cub.2012.11.016

Aging: One thing leads to another

Marion Schmidt, Brian K. Kennedy

Biochemistry

Research output: Contribution to journal › Short survey › peer-review

6 Scopus citations

Abstract

Mitochondria deteriorate during the aging process, but the underlying mechanisms for the decline of this critical organelle are unknown. A new study indicates that in yeast an age-dependent reduction in vacuolar acidification leads to mitochondrial dysfunction through a surprising mechanism: loss of vacuolar neutral amino acid transport.

Original language	English (US)
Pages (from-to)	R1048-R1051
Journal	Current Biology
Volume	22
Issue number	24
DOIs	https://doi.org/10.1016/j.cub.2012.11.016
State	Published - Dec 18 2012

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
General Agricultural and Biological Sciences

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10.1016/j.cub.2012.11.016

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title = "Aging: One thing leads to another",

abstract = "Mitochondria deteriorate during the aging process, but the underlying mechanisms for the decline of this critical organelle are unknown. A new study indicates that in yeast an age-dependent reduction in vacuolar acidification leads to mitochondrial dysfunction through a surprising mechanism: loss of vacuolar neutral amino acid transport.",

author = "Marion Schmidt and Kennedy, {Brian K.}",

year = "2012",

month = dec,

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doi = "10.1016/j.cub.2012.11.016",

language = "English (US)",

volume = "22",

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journal = "Current Biology",

issn = "0960-9822",

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TY - JOUR

T1 - Aging

T2 - One thing leads to another

AU - Schmidt, Marion

AU - Kennedy, Brian K.

PY - 2012/12/18

Y1 - 2012/12/18

N2 - Mitochondria deteriorate during the aging process, but the underlying mechanisms for the decline of this critical organelle are unknown. A new study indicates that in yeast an age-dependent reduction in vacuolar acidification leads to mitochondrial dysfunction through a surprising mechanism: loss of vacuolar neutral amino acid transport.

AB - Mitochondria deteriorate during the aging process, but the underlying mechanisms for the decline of this critical organelle are unknown. A new study indicates that in yeast an age-dependent reduction in vacuolar acidification leads to mitochondrial dysfunction through a surprising mechanism: loss of vacuolar neutral amino acid transport.

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U2 - 10.1016/j.cub.2012.11.016

DO - 10.1016/j.cub.2012.11.016

M3 - Short survey

C2 - 23257191

AN - SCOPUS:84871279766

SN - 0960-9822

VL - 22

SP - R1048-R1051

JO - Current Biology

JF - Current Biology

IS - 24

ER -

Aging: One thing leads to another

Abstract

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