Abstract
Twenty-five patients with acute asthma were randomized prospectively into one of two double-blind treatment regimens: regimen 1 consisted of subcutaneous epinephrine combined with aerosol placebo; regimen 2 consisted of aerosol epinephrine with injected placebo. In patients with severe airway obstruction (peak expiratory flow rate ≤ 120, or ≤ 25% of predicted normal), parenteral epinephrine was superior to aerosol (P < 0.005) at the end of one hour. However, in patients with mild to moderate asthma (PEFR>120), injected and inhaled epinephrine were of equal efficacy, with the aerosol producing fewer side effects (P < 0.001).
Original language | English (US) |
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Pages (from-to) | 353-355 |
Number of pages | 3 |
Journal | Annals of emergency medicine |
Volume | 10 |
Issue number | 7 |
DOIs | |
State | Published - Jul 1981 |
Keywords
- asthma
- asthma treatment
- epinephrine
- treatment
ASJC Scopus subject areas
- Emergency Medicine