Abstract
Most patients with multidrug-resistant tuberculosis (MDR-TB) in South Africa are HIV-infected, but the safety and tolerability of cotreatment are unknown. The authors reviewed all adverse events (AEs) for patients with MDR-TB in a home-based treatment program in rural KwaZulu-Natal. Of 91 MDR-TB patients, 74 (81%) were HIV-positive and receiving antiretroviral therapy. AEs were common, but most were mild and did not require therapy modification. The most common severe AEs were hypothyroidism (36%) and psychosis (5%). Patients receiving concurrent antiretroviral therapy did not experience AEs more frequently than those on MDR-TB therapy alone. Concurrent treatment for MDR-TB/HIV can be safely administered in a homebased care setting.
Original language | English (US) |
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Pages (from-to) | 436-440 |
Number of pages | 5 |
Journal | Journal of Acquired Immune Deficiency Syndromes |
Volume | 62 |
Issue number | 4 |
DOIs | |
State | Published - Apr 1 2013 |
Keywords
- Adverse events
- HIV
- Multidrug-resistant tuberculosis
- Resource-limited settings
- Side effects
ASJC Scopus subject areas
- Infectious Diseases
- Pharmacology (medical)