Advances in fungal peptide vaccines

Leandro B.R. Da Silva, Carlos P. Taborda, Joshua D. Nosanchuk

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Vaccination is one of the greatest public health achievements in the past century, protecting and improving the quality of life of the population worldwide. However, a safe and effective vaccine for therapeutic or prophylactic treatment of fungal infections is not yet available. The lack of a vaccine for fungi is a problem of increasing importance as the incidence of diverse species, including Paracoccidioides, Aspergillus, Candida, Sporothrix, and Coccidioides, has increased in recent decades and new drug-resistant pathogenic fungi are emerging. In fact, our antifungal armamentarium too frequently fails to effectively control or cure mycoses, leading to high rates of mortality and morbidity. With this in mind, many groups are working towards identifying effective and safe vaccines for fungal pathogens, with a particular focus of generating vaccines that will work in individuals with compromised immunity who bear the major burden of infections from these microbes. In this review, we detail advances in the development of vaccines for pathogenic fungi, and highlight new methodologies using immunoproteomic techniques and bioinformatic tools that have led to new vaccine formulations, like peptide-based vaccines.

Original languageEnglish (US)
Article number119
Pages (from-to)1-18
Number of pages18
JournalJournal of Fungi
Issue number3
StatePublished - Sep 2020


  • Aspergillus
  • Candida
  • Coccidioides
  • Dendritic cells
  • Fungal
  • Paracoccidioides
  • Peptides
  • Sporothrix
  • Vaccine

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Plant Science
  • Microbiology (medical)


Dive into the research topics of 'Advances in fungal peptide vaccines'. Together they form a unique fingerprint.

Cite this