Advanced ovarian dysgerminoma with cure of tumor persistent in meninges

Christopher J. Jolles, Sharon Karayianis, David Smotkin, Julian E. DeLia

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Isolated meningeal recurrence of ovarian cancer is uncommon. It is generally assumed that such cases are not accompanied by prolonged survival. We report the cure of a patient with advanced ovarian dysgerminoma who developed febrile carcinomatous meningitis 2 weeks after receiving her fifth course of combination chemotherapy (5 months after initiation of chemotherapy). No parenchymal brain disease was identified. The persistence of disease in the leptomeninges is related to the ability of the blood-brain barrier to exclude chemotherapeutic agents. The patient responded to craniospinal radiation and remains free of disease 2 years after completion of treatment.

Original languageEnglish (US)
Pages (from-to)389-391
Number of pages3
JournalGynecologic Oncology
Issue number3
StatePublished - Jun 1989
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology


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