Advanced glycation end product carboxymethyl-lysine and risk of incident peripheral artery disease in older adults: The Cardiovascular Health Study

Parveen K. Garg; Mary L. Biggs; Joshua Barzilay; Luc Djousse; Calvin Hirsch; Joachim H. Ix; Jorge R. Kizer; Russell P. Tracy; Anne B. Newman; David S. Siscovick; Kenneth J. Mukamal

doi:10.1177/1479164119847481

Advanced glycation end product carboxymethyl-lysine and risk of incident peripheral artery disease in older adults: The Cardiovascular Health Study

Parveen K. Garg, Mary L. Biggs, Joshua Barzilay, Luc Djousse, Calvin Hirsch, Joachim H. Ix, Jorge R. Kizer, Russell P. Tracy, Anne B. Newman, David S. Siscovick, Kenneth J. Mukamal

Medicine

Research output: Contribution to journal › Letter › peer-review

5 Scopus citations

Abstract

Carboxymethyl-lysine is an advanced glycation end product that is detectable in the serum. Higher carboxymethyl-lysine levels have been associated with increased risk of coronary heart disease, stroke and cardiovascular mortality. We determined whether high carboxymethyl-lysine levels are also associated with the risk of peripheral artery disease in Cardiovascular Health Study participants who were all aged 65 years and older at baseline. Multivariate Cox proportional hazards models were used to determine the association of baseline carboxymethyl-lysine levels with incident peripheral artery disease in 3267 individuals followed for a median length of 10.0 years. A total of 157 cases of incident peripheral artery disease occurred during follow-up. No significant relationship between carboxymethyl-lysine and risk of peripheral artery disease was found (hazard ratio per standard deviation increment = 1.03; 95% confidence interval = 0.87, 1.23).

Original language	English (US)
Pages (from-to)	483-485
Number of pages	3
Journal	Diabetes and Vascular Disease Research
Volume	16
Issue number	5
DOIs	https://doi.org/10.1177/1479164119847481
State	Published - Sep 1 2019

Keywords

Advanced glycation end products
ankle–brachial index
inflammation
peripheral artery disease

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Cardiology and Cardiovascular Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1177/1479164119847481

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Garg, P. K., Biggs, M. L., Barzilay, J., Djousse, L., Hirsch, C., Ix, J. H., Kizer, J. R., Tracy, R. P., Newman, A. B., Siscovick, D. S., & Mukamal, K. J. (2019). Advanced glycation end product carboxymethyl-lysine and risk of incident peripheral artery disease in older adults: The Cardiovascular Health Study. Diabetes and Vascular Disease Research, 16(5), 483-485. https://doi.org/10.1177/1479164119847481

Garg, PK, Biggs, ML, Barzilay, J, Djousse, L, Hirsch, C, Ix, JH, Kizer, JR, Tracy, RP, Newman, AB, Siscovick, DS & Mukamal, KJ 2019, 'Advanced glycation end product carboxymethyl-lysine and risk of incident peripheral artery disease in older adults: The Cardiovascular Health Study', Diabetes and Vascular Disease Research, vol. 16, no. 5, pp. 483-485. https://doi.org/10.1177/1479164119847481

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title = "Advanced glycation end product carboxymethyl-lysine and risk of incident peripheral artery disease in older adults: The Cardiovascular Health Study",

abstract = "Carboxymethyl-lysine is an advanced glycation end product that is detectable in the serum. Higher carboxymethyl-lysine levels have been associated with increased risk of coronary heart disease, stroke and cardiovascular mortality. We determined whether high carboxymethyl-lysine levels are also associated with the risk of peripheral artery disease in Cardiovascular Health Study participants who were all aged 65 years and older at baseline. Multivariate Cox proportional hazards models were used to determine the association of baseline carboxymethyl-lysine levels with incident peripheral artery disease in 3267 individuals followed for a median length of 10.0 years. A total of 157 cases of incident peripheral artery disease occurred during follow-up. No significant relationship between carboxymethyl-lysine and risk of peripheral artery disease was found (hazard ratio per standard deviation increment = 1.03; 95% confidence interval = 0.87, 1.23).",

keywords = "Advanced glycation end products, ankle–brachial index, inflammation, peripheral artery disease",

author = "Garg, {Parveen K.} and Biggs, {Mary L.} and Joshua Barzilay and Luc Djousse and Calvin Hirsch and Ix, {Joachim H.} and Kizer, {Jorge R.} and Tracy, {Russell P.} and Newman, {Anne B.} and Siscovick, {David S.} and Mukamal, {Kenneth J.}",

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doi = "10.1177/1479164119847481",

language = "English (US)",

volume = "16",

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T1 - Advanced glycation end product carboxymethyl-lysine and risk of incident peripheral artery disease in older adults

T2 - The Cardiovascular Health Study

AU - Garg, Parveen K.

AU - Biggs, Mary L.

AU - Barzilay, Joshua

AU - Djousse, Luc

AU - Hirsch, Calvin

AU - Ix, Joachim H.

AU - Kizer, Jorge R.

AU - Tracy, Russell P.

AU - Newman, Anne B.

AU - Siscovick, David S.

AU - Mukamal, Kenneth J.

PY - 2019/9/1

Y1 - 2019/9/1

N2 - Carboxymethyl-lysine is an advanced glycation end product that is detectable in the serum. Higher carboxymethyl-lysine levels have been associated with increased risk of coronary heart disease, stroke and cardiovascular mortality. We determined whether high carboxymethyl-lysine levels are also associated with the risk of peripheral artery disease in Cardiovascular Health Study participants who were all aged 65 years and older at baseline. Multivariate Cox proportional hazards models were used to determine the association of baseline carboxymethyl-lysine levels with incident peripheral artery disease in 3267 individuals followed for a median length of 10.0 years. A total of 157 cases of incident peripheral artery disease occurred during follow-up. No significant relationship between carboxymethyl-lysine and risk of peripheral artery disease was found (hazard ratio per standard deviation increment = 1.03; 95% confidence interval = 0.87, 1.23).

AB - Carboxymethyl-lysine is an advanced glycation end product that is detectable in the serum. Higher carboxymethyl-lysine levels have been associated with increased risk of coronary heart disease, stroke and cardiovascular mortality. We determined whether high carboxymethyl-lysine levels are also associated with the risk of peripheral artery disease in Cardiovascular Health Study participants who were all aged 65 years and older at baseline. Multivariate Cox proportional hazards models were used to determine the association of baseline carboxymethyl-lysine levels with incident peripheral artery disease in 3267 individuals followed for a median length of 10.0 years. A total of 157 cases of incident peripheral artery disease occurred during follow-up. No significant relationship between carboxymethyl-lysine and risk of peripheral artery disease was found (hazard ratio per standard deviation increment = 1.03; 95% confidence interval = 0.87, 1.23).

KW - Advanced glycation end products

KW - ankle–brachial index

KW - inflammation

KW - peripheral artery disease

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JO - Diabetes and Vascular Disease Research

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ER -

Advanced glycation end product carboxymethyl-lysine and risk of incident peripheral artery disease in older adults: The Cardiovascular Health Study

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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