Advanced development of the digital tuberculosis tester for MDR-TB screening

Jason E. Smith, Michelle D. Simkulet, Alexander Gutin, Alexy Gutin, Savco Bardarov, William R. Jacobs, James Castracane, Oliver Tang, Paul Riska

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Tuberculosis (TB) remains the leading cause of death in the world from a single infectious disease, and the threat is becoming more critical with the spread of multi-drug resistant Tuberculosis MDR-TB). TB detection, and susceptibility testing for drug resistant strain identification, is advancing with the development of Luciferase Reporter Mycobacteriophages (LRM). Luciferase Reporter Mycobacteriophages will emit visible light at very low intensity when in the presence of live mycobacteria cells such as Tuberculosis strains. InterScience, Inc., together with its collaborators, is developing a highly sensitive, real-time digital detection system for the analysis of luminescent assays. Recent advances in system sensitivity, design, and implementation, as well as preliminary results of the development of individual test cartridges, will be presented. The ultimate goal of this work is to provide a versatile luminescence detection tool for widespread research and clinical applications.

Original languageEnglish (US)
Pages (from-to)9-15
Number of pages7
JournalProceedings of SPIE - The International Society for Optical Engineering
StatePublished - 2001


  • Cooled CCD
  • Digital imaging
  • LRM Assay
  • Luminescence
  • Tuberculosis

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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