Adrenergic signaling in heart failure and cardiovascular aging

Gaetano Santulli, Guido Iaccarino

Research output: Contribution to journalReview articlepeer-review

76 Scopus citations


Both cardiovascular disease and aging are associated with changes in the sympathetic nervous system. Indeed, mounting evidence indicates that adrenergic receptors are functionally involved in numerous processes underlying both aging and cardiovascular disorders, in particular heart failure. This article will review the pathophysiological role of the sympathetic nervous system in heart failure and cardiovascular aging.

Original languageEnglish (US)
Pages (from-to)65-72
Number of pages8
StatePublished - Nov 1 2016
Externally publishedYes


  • Aging
  • Beta adrenergic receptors
  • Cardiovascular system
  • G protein-coupled receptor kinases
  • Heart failure
  • Multimorbidity
  • Sympathetic nervous system

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • Obstetrics and Gynecology


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