Adaptive induction of NF-E2-related factor-2-driven antioxidant genes in endothelial cells in response to hyperglycemia

Keyphrases

• Hyperglycemia 100%
• Endothelial Cells 100%
• Nuclear Factor Erythroid 2-related Factor 2 (Nrf2) 100%
• Antioxidant Genes 100%
• High-fat Diet 29%
• High Glucose 17%
• Heme oxygenase-1 (HO-1) 17%
• Oxidative Stress 11%
• Diet-induced 11%
• Aorta 11%
• Antioxidant Response Element 11%
• Diabetes Distress 11%
• Endothelial Protection 11%
• NAD(P)H:Quinone Oxidoreductase 1 (NQO1) 11%
• Transcriptional Activity 5%
• Cardiovascular Disease 5%
• Transcription Factor 5%
• Overexpression 5%
• Catalase 5%
• Acetylcholine 5%
• Reactive Oxygen Species 5%
• Kelch-like ECH-associated Protein 1 (Keap1) 5%
• Detoxification Mechanism 5%
• MRNA Expression 5%
• Hydrogen Peroxide 5%
• N-acetylcysteine 5%
• Small Interfering RNA (siRNA) 5%
• Endothelial Dysfunction 5%
• L-glucose 5%
• Polyethylene Glycol 5%
• Free Radicals 5%
• Luciferase Reporter Assay 5%
• Metabolic Stress 5%
• Adaptive Behavior 5%
• Detoxification Genes 5%
• Coronary Artery Endothelial Cells 5%
• Gclc 5%
• Diabetes Mellitus 5%
• Feeding Control 5%
• Reactive Oxygen Species Levels 5%

Biochemistry, Genetics and Molecular Biology

• Hyperglycemia 100%
• Transcription Factor Nrf2 100%
• Antioxidant Gene 100%
• Glucose 23%
• Oxidative Stress 11%
• Antioxidant Responsive Element 11%
• Glutamate Cysteine Ligase Catalytic 11%
• HMOX1 11%
• Upregulation 5%
• Transcription Factors 5%
• Downregulation 5%
• Reporter Gene 5%
• Luciferase 5%
• Catalase 5%
• Nuclear Factor Erythroid-2-Related Factor 2 5%
• Messenger RNA 5%
• Acetylcholine 5%
• Acetylcysteine 5%
• Small Interfering RNA 5%

Immunology and Microbiology

• Transcription Factor Nrf2 100%
• Endothelial Cells 100%
• Glucose 22%
• Oxidative Stress 11%
• Antioxidant Responsive Element 11%
• Dioxygen 11%
• Transcription Factors 5%
• Downregulation 5%
• Upregulation 5%
• Reporter Gene 5%
• Cardiovascular System 5%
• Catalase 5%
• Ribonucleic Acid 5%
• Acetylcholine 5%
• Polyethylene Glycol 5%
• Pretreatment 5%