TY - JOUR
T1 - Acute migraine medication adherence, migraine disability and patient satisfaction
T2 - A naturalistic daily diary study
AU - Seng, Elizabeth K.
AU - Robbins, Matthew S.
AU - Nicholson, Robert A.
N1 - Funding Information:
The authors declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: Dr Seng receives research support from the National Institute of Health [1K23NS096107-01 (PI: Seng)] and the International Headache Academy (PI: Seng); she serves as a consultant or has received honoraria or travel funding from the American Academy of Neurology, American Psychological Association Commission on Accreditation, and GlaxoSmithKline.
Publisher Copyright:
© International Headache Society.
PY - 2017/9/1
Y1 - 2017/9/1
N2 - Objective To examine the influence of acute migraine medication adherence on migraine disability and acute medication satisfaction. Methods Adults with migraine completed three months of daily electronic diaries assessing headache symptoms, acute medication taken, acute medication satisfaction, and daily migraine disability. Repeated measures mixed-effects models examined the effect of initial medication type [migraine-specific medication (MSM) vs. over-the-counter analgesic (OTC) vs. an opiate/barbiturate], the severity of pain at dosing, and their interaction with daily migraine disability and satisfaction with acute medication. Results Participants (N = 337; 92.5% female; 91.1% Caucasian, non-Hispanic; 84.0% with episodic migraine) recorded 29,722 diary days. Participants took acute medication on 96.5% of 8090 migraine days. MSM was most frequently taken first (58%), followed by OTC (29.9%) and an opiate/barbiturate (12.1%). Acute medication was most frequently taken when pain was mild (41.2%), followed by moderate (37.7%) and severe pain (11.4%). Initially dosing with MSM while pain was mild was associated with the lowest daily disability [medication × pain at dosing F (4, 6336.12) = 58.73, p <.001] and highest acute medication satisfaction [medication × pain at dosing F (4, 3867.36) = 24.00, p <.001]. Conclusion Using an MSM (triptan or ergot) first was associated with the lowest migraine disability and highest acute medication satisfaction.
AB - Objective To examine the influence of acute migraine medication adherence on migraine disability and acute medication satisfaction. Methods Adults with migraine completed three months of daily electronic diaries assessing headache symptoms, acute medication taken, acute medication satisfaction, and daily migraine disability. Repeated measures mixed-effects models examined the effect of initial medication type [migraine-specific medication (MSM) vs. over-the-counter analgesic (OTC) vs. an opiate/barbiturate], the severity of pain at dosing, and their interaction with daily migraine disability and satisfaction with acute medication. Results Participants (N = 337; 92.5% female; 91.1% Caucasian, non-Hispanic; 84.0% with episodic migraine) recorded 29,722 diary days. Participants took acute medication on 96.5% of 8090 migraine days. MSM was most frequently taken first (58%), followed by OTC (29.9%) and an opiate/barbiturate (12.1%). Acute medication was most frequently taken when pain was mild (41.2%), followed by moderate (37.7%) and severe pain (11.4%). Initially dosing with MSM while pain was mild was associated with the lowest daily disability [medication × pain at dosing F (4, 6336.12) = 58.73, p <.001] and highest acute medication satisfaction [medication × pain at dosing F (4, 3867.36) = 24.00, p <.001]. Conclusion Using an MSM (triptan or ergot) first was associated with the lowest migraine disability and highest acute medication satisfaction.
KW - Migraine
KW - acute drug therapy
KW - adherence
KW - disability
KW - patient satisfaction
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U2 - 10.1177/0333102416663459
DO - 10.1177/0333102416663459
M3 - Article
C2 - 27489178
AN - SCOPUS:85028975680
SN - 0333-1024
VL - 37
SP - 955
EP - 964
JO - Cephalalgia
JF - Cephalalgia
IS - 10
ER -