Acute megakaryoblastic leukemia mimicking small round cell tumor with novel t(1;5)(q21;p13)

Suheyla Uyar Bozkurt, Su Gulsun Berrak, Halil Tugtepe, Cengiz Canpolat, Sukru Palanduz, Tulay Tecimer

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Acute megakaryoblastic leukemia is a relatively rare form of acute leukemia that has heterogeneous blast morphology and karyotypic abnormalities. An 8-month-old boy with a retroperitoneal mass was diagnosed as having acute megakaryoblastic leukemia that initially presented as small round cell tumor of childhood. Bone marrow aspiration showed syncytial groups of atypical medium sized cells with scant cytoplasm and fine nuclear chromatin. Retroperitoneal mass biopsy showed several lymph nodes with cohesive clusters of neoplastic cells that demonstrated expression of Factor VIII. Flow cytometric analysis of the second bone marrow aspiration showed CD 61 positivity. Karyotypic analysis of bone marrow cells showed a novel translocation, (1;5)(q21;p13).

Original languageEnglish (US)
Pages (from-to)163-166
Number of pages4
Issue number2
StatePublished - Feb 2008
Externally publishedYes


  • Acute megakaryoblastic leukemia
  • Cytogenetics
  • Metastatic carcinoma
  • Small round cell tumor
  • t(1;5)

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Immunology and Allergy
  • Microbiology (medical)


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