Acute Kidney Injury and Bronchopulmonary Dysplasia in Premature Neonates Born Less than 32 Weeks' Gestation

Michelle C. Starr; Louis Boohaker; Laurie C. Eldredge; Shina Menon; Russell Griffin; Dennis E. Mayock; Linzi Li; David Askenazi; Sangeeta Hingorani; Namasivayam Ambalavanan; David T. Selewski; Subrata Sarkar; Alison Kent; Jeffery Fletcher; Carolyn L. Abitbol; Marissa Defreitas; Shahnaz Duara; Jennifer R. Charlton; Jonathan R. Swanson; Ronnie Guillet; Carl D'Angio; Ayesa Mian; Erin Rademacher; Maroun J. Mhanna; Rupesh Raina; Deepak Kumar; Jennifer G. Jetton; Patrick D. Brophy; Tarah T. Colaizy; Jonathan M. Klein; Ayse Akcan Arikan; Christopher J. Rhee; Stuart L. Goldstein; Amy T. Nathan; Juan C. Kupferman; Alok Bhutada; Shantanu Rastogi; Elizabeth Bonachea; John Mahan; F. Sessions Cole; T. Keefe Davis; Joshua Dower; Lawrence Milner; Alexandra Smith; Mamta Fuloria; Kimberly Reidy; Frederick J. Kaskel; Danielle E. Soranno; Jason Gien; Katja M. Gist; Aftab S. Chishti; Mina H. Hanna; Craig S. Wong; Catherine Joseph; Tara Dupont; Robin Ohls; Amy Staples; Surender Khokhar; Sofia Perazzo; Patricio E. Ray; Mary Revenis; Sidharth K. Sethi; Smriri Rohatgi; Cherry Mammen; Anne Synnes; Sanjay Wazir; Pia Wintermark; Robert Woroniecki; Shanty Sridhar; Susan Ingraham; Arwa Nada; Michael Zappitelli

doi:10.1055/s-0039-3400311

Acute Kidney Injury and Bronchopulmonary Dysplasia in Premature Neonates Born Less than 32 Weeks' Gestation

Michelle C. Starr, Louis Boohaker, Laurie C. Eldredge, Shina Menon, Russell Griffin, Dennis E. Mayock, Linzi Li, David Askenazi, Sangeeta Hingorani, Namasivayam Ambalavanan, David T. Selewski, Subrata Sarkar, Alison Kent, Jeffery Fletcher, Carolyn L. Abitbol, Marissa Defreitas, Shahnaz Duara, Jennifer R. Charlton, Jonathan R. Swanson, Ronnie GuilletCarl D'Angio, Ayesa Mian, Erin Rademacher, Maroun J. Mhanna, Rupesh Raina, Deepak Kumar, Jennifer G. Jetton, Patrick D. Brophy, Tarah T. Colaizy, Jonathan M. Klein, Ayse Akcan Arikan, Christopher J. Rhee, Stuart L. Goldstein, Amy T. Nathan, Juan C. Kupferman, Alok Bhutada, Shantanu Rastogi, Elizabeth Bonachea, John Mahan, F. Sessions Cole, T. Keefe Davis, Joshua Dower, Lawrence Milner, Alexandra Smith, Mamta Fuloria, Kimberly Reidy, Frederick J. Kaskel, Danielle E. Soranno, Jason Gien, Katja M. Gist, Aftab S. Chishti, Mina H. Hanna, Craig S. Wong, Catherine Joseph, Tara Dupont, Robin Ohls, Amy Staples, Surender Khokhar, Sofia Perazzo, Patricio E. Ray, Mary Revenis, Sidharth K. Sethi, Smriri Rohatgi, Cherry Mammen, Anne Synnes, Sanjay Wazir, Pia Wintermark, Robert Woroniecki, Shanty Sridhar, Susan Ingraham, Arwa Nada, Michael Zappitelli

Pediatrics

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Objective This study aimed to evaluate the association between acute kidney injury (AKI) and bronchopulmonary dysplasia (BPD) in infants born <32 weeks of gestational age (GA). Study Design Present study is a secondary analysis of premature infants born at <32 weeks of GA in the Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates (AWAKEN) retrospective cohort (n = 546). We stratified by gestational age and used logistic regression to determine association between AKI and moderate or severe BPD/mortality. Results Moderate or severe BPD occurred in 214 of 546 (39%) infants, while death occurred in 32 of 546 (6%); the composite of moderate or severe BPD/death occurred in 246 of 546 (45%). For infants born ≤29 weeks of gestation, the adjusted odds ratio (OR) of AKI and the primary outcome was 1.15 (95% confidence interval [CI] = 0.47-2.86; p = 0.76). Infants born between 29 and 32 weeks of gestation with AKI had four-fold higher odds of moderate or severe BPD/death that remained after controlling for multiple factors (adjusted OR = 4.21, 95% CI: 2.07-8.61; p < 0.001). Conclusion Neonates born between 29 and 32 weeks who develop AKI had a higher likelihood of moderate or severe BPD/death than those without AKI. Further studies are needed to validate our findings and evaluate mechanisms of multiorgan injury.

Original language	English (US)
Pages (from-to)	341-348
Number of pages	8
Journal	American Journal of Perinatology
Volume	37
Issue number	3
DOIs	https://doi.org/10.1055/s-0039-3400311
State	Published - Feb 1 2020

Keywords

acute lung injury
acute renal failure
bronchopulmonary dysplasia
chronic lung disease
neonate
organ crosstalk
prematurity

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynecology

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10.1055/s-0039-3400311

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Starr, M. C., Boohaker, L., Eldredge, L. C., Menon, S., Griffin, R., Mayock, D. E., Li, L., Askenazi, D., Hingorani, S., Ambalavanan, N., Selewski, D. T., Sarkar, S., Kent, A., Fletcher, J., Abitbol, C. L., Defreitas, M., Duara, S., Charlton, J. R., Swanson, J. R., ... Zappitelli, M. (2020). Acute Kidney Injury and Bronchopulmonary Dysplasia in Premature Neonates Born Less than 32 Weeks' Gestation. American Journal of Perinatology, 37(3), 341-348. https://doi.org/10.1055/s-0039-3400311

Starr, MC, Boohaker, L, Eldredge, LC, Menon, S, Griffin, R, Mayock, DE, Li, L, Askenazi, D, Hingorani, S, Ambalavanan, N, Selewski, DT, Sarkar, S, Kent, A, Fletcher, J, Abitbol, CL, Defreitas, M, Duara, S, Charlton, JR, Swanson, JR, Guillet, R, D'Angio, C, Mian, A, Rademacher, E, Mhanna, MJ, Raina, R, Kumar, D, Jetton, JG, Brophy, PD, Colaizy, TT, Klein, JM, Arikan, AA, Rhee, CJ, Goldstein, SL, Nathan, AT, Kupferman, JC, Bhutada, A, Rastogi, S, Bonachea, E, Mahan, J, Cole, FS, Davis, TK, Dower, J, Milner, L, Smith, A, Fuloria, M , Reidy, K , Kaskel, FJ, Soranno, DE, Gien, J, Gist, KM, Chishti, AS, Hanna, MH, Wong, CS, Joseph, C, Dupont, T, Ohls, R, Staples, A, Khokhar, S, Perazzo, S, Ray, PE, Revenis, M, Sethi, SK, Rohatgi, S, Mammen, C, Synnes, A, Wazir, S, Wintermark, P, Woroniecki, R, Sridhar, S, Ingraham, S, Nada, A & Zappitelli, M 2020, 'Acute Kidney Injury and Bronchopulmonary Dysplasia in Premature Neonates Born Less than 32 Weeks' Gestation', American Journal of Perinatology, vol. 37, no. 3, pp. 341-348. https://doi.org/10.1055/s-0039-3400311

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title = "Acute Kidney Injury and Bronchopulmonary Dysplasia in Premature Neonates Born Less than 32 Weeks' Gestation",

abstract = "Objective This study aimed to evaluate the association between acute kidney injury (AKI) and bronchopulmonary dysplasia (BPD) in infants born <32 weeks of gestational age (GA). Study Design Present study is a secondary analysis of premature infants born at <32 weeks of GA in the Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates (AWAKEN) retrospective cohort (n = 546). We stratified by gestational age and used logistic regression to determine association between AKI and moderate or severe BPD/mortality. Results Moderate or severe BPD occurred in 214 of 546 (39%) infants, while death occurred in 32 of 546 (6%); the composite of moderate or severe BPD/death occurred in 246 of 546 (45%). For infants born ≤29 weeks of gestation, the adjusted odds ratio (OR) of AKI and the primary outcome was 1.15 (95% confidence interval [CI] = 0.47-2.86; p = 0.76). Infants born between 29 and 32 weeks of gestation with AKI had four-fold higher odds of moderate or severe BPD/death that remained after controlling for multiple factors (adjusted OR = 4.21, 95% CI: 2.07-8.61; p < 0.001). Conclusion Neonates born between 29 and 32 weeks who develop AKI had a higher likelihood of moderate or severe BPD/death than those without AKI. Further studies are needed to validate our findings and evaluate mechanisms of multiorgan injury.",

keywords = "acute lung injury, acute renal failure, bronchopulmonary dysplasia, chronic lung disease, neonate, organ crosstalk, prematurity",

author = "Starr, {Michelle C.} and Louis Boohaker and Eldredge, {Laurie C.} and Shina Menon and Russell Griffin and Mayock, {Dennis E.} and Linzi Li and David Askenazi and Sangeeta Hingorani and Namasivayam Ambalavanan and Selewski, {David T.} and Subrata Sarkar and Alison Kent and Jeffery Fletcher and Abitbol, {Carolyn L.} and Marissa Defreitas and Shahnaz Duara and Charlton, {Jennifer R.} and Swanson, {Jonathan R.} and Ronnie Guillet and Carl D'Angio and Ayesa Mian and Erin Rademacher and Mhanna, {Maroun J.} and Rupesh Raina and Deepak Kumar and Jetton, {Jennifer G.} and Brophy, {Patrick D.} and Colaizy, {Tarah T.} and Klein, {Jonathan M.} and Arikan, {Ayse Akcan} and Rhee, {Christopher J.} and Goldstein, {Stuart L.} and Nathan, {Amy T.} and Kupferman, {Juan C.} and Alok Bhutada and Shantanu Rastogi and Elizabeth Bonachea and John Mahan and Cole, {F. Sessions} and Davis, {T. Keefe} and Joshua Dower and Lawrence Milner and Alexandra Smith and Mamta Fuloria and Kimberly Reidy and Kaskel, {Frederick J.} and Soranno, {Danielle E.} and Jason Gien and Gist, {Katja M.} and Chishti, {Aftab S.} and Hanna, {Mina H.} and Wong, {Craig S.} and Catherine Joseph and Tara Dupont and Robin Ohls and Amy Staples and Surender Khokhar and Sofia Perazzo and Ray, {Patricio E.} and Mary Revenis and Sethi, {Sidharth K.} and Smriri Rohatgi and Cherry Mammen and Anne Synnes and Sanjay Wazir and Pia Wintermark and Robert Woroniecki and Shanty Sridhar and Susan Ingraham and Arwa Nada and Michael Zappitelli",

year = "2020",

month = feb,

day = "1",

doi = "10.1055/s-0039-3400311",

language = "English (US)",

volume = "37",

pages = "341--348",

journal = "American Journal of Perinatology",

issn = "0735-1631",

publisher = "Thieme Medical Publishers",

number = "3",

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TY - JOUR

T1 - Acute Kidney Injury and Bronchopulmonary Dysplasia in Premature Neonates Born Less than 32 Weeks' Gestation

AU - Starr, Michelle C.

AU - Boohaker, Louis

AU - Eldredge, Laurie C.

AU - Menon, Shina

AU - Griffin, Russell

AU - Mayock, Dennis E.

AU - Li, Linzi

AU - Askenazi, David

AU - Hingorani, Sangeeta

AU - Ambalavanan, Namasivayam

AU - Selewski, David T.

AU - Sarkar, Subrata

AU - Kent, Alison

AU - Fletcher, Jeffery

AU - Abitbol, Carolyn L.

AU - Defreitas, Marissa

AU - Duara, Shahnaz

AU - Charlton, Jennifer R.

AU - Swanson, Jonathan R.

AU - Guillet, Ronnie

AU - D'Angio, Carl

AU - Mian, Ayesa

AU - Rademacher, Erin

AU - Mhanna, Maroun J.

AU - Raina, Rupesh

AU - Kumar, Deepak

AU - Jetton, Jennifer G.

AU - Brophy, Patrick D.

AU - Colaizy, Tarah T.

AU - Klein, Jonathan M.

AU - Arikan, Ayse Akcan

AU - Rhee, Christopher J.

AU - Goldstein, Stuart L.

AU - Nathan, Amy T.

AU - Kupferman, Juan C.

AU - Bhutada, Alok

AU - Rastogi, Shantanu

AU - Bonachea, Elizabeth

AU - Mahan, John

AU - Cole, F. Sessions

AU - Davis, T. Keefe

AU - Dower, Joshua

AU - Milner, Lawrence

AU - Smith, Alexandra

AU - Fuloria, Mamta

AU - Reidy, Kimberly

AU - Kaskel, Frederick J.

AU - Soranno, Danielle E.

AU - Gien, Jason

AU - Gist, Katja M.

AU - Chishti, Aftab S.

AU - Hanna, Mina H.

AU - Wong, Craig S.

AU - Joseph, Catherine

AU - Dupont, Tara

AU - Ohls, Robin

AU - Staples, Amy

AU - Khokhar, Surender

AU - Perazzo, Sofia

AU - Ray, Patricio E.

AU - Revenis, Mary

AU - Sethi, Sidharth K.

AU - Rohatgi, Smriri

AU - Mammen, Cherry

AU - Synnes, Anne

AU - Wazir, Sanjay

AU - Wintermark, Pia

AU - Woroniecki, Robert

AU - Sridhar, Shanty

AU - Ingraham, Susan

AU - Nada, Arwa

AU - Zappitelli, Michael

PY - 2020/2/1

Y1 - 2020/2/1

N2 - Objective This study aimed to evaluate the association between acute kidney injury (AKI) and bronchopulmonary dysplasia (BPD) in infants born <32 weeks of gestational age (GA). Study Design Present study is a secondary analysis of premature infants born at <32 weeks of GA in the Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates (AWAKEN) retrospective cohort (n = 546). We stratified by gestational age and used logistic regression to determine association between AKI and moderate or severe BPD/mortality. Results Moderate or severe BPD occurred in 214 of 546 (39%) infants, while death occurred in 32 of 546 (6%); the composite of moderate or severe BPD/death occurred in 246 of 546 (45%). For infants born ≤29 weeks of gestation, the adjusted odds ratio (OR) of AKI and the primary outcome was 1.15 (95% confidence interval [CI] = 0.47-2.86; p = 0.76). Infants born between 29 and 32 weeks of gestation with AKI had four-fold higher odds of moderate or severe BPD/death that remained after controlling for multiple factors (adjusted OR = 4.21, 95% CI: 2.07-8.61; p < 0.001). Conclusion Neonates born between 29 and 32 weeks who develop AKI had a higher likelihood of moderate or severe BPD/death than those without AKI. Further studies are needed to validate our findings and evaluate mechanisms of multiorgan injury.

AB - Objective This study aimed to evaluate the association between acute kidney injury (AKI) and bronchopulmonary dysplasia (BPD) in infants born <32 weeks of gestational age (GA). Study Design Present study is a secondary analysis of premature infants born at <32 weeks of GA in the Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates (AWAKEN) retrospective cohort (n = 546). We stratified by gestational age and used logistic regression to determine association between AKI and moderate or severe BPD/mortality. Results Moderate or severe BPD occurred in 214 of 546 (39%) infants, while death occurred in 32 of 546 (6%); the composite of moderate or severe BPD/death occurred in 246 of 546 (45%). For infants born ≤29 weeks of gestation, the adjusted odds ratio (OR) of AKI and the primary outcome was 1.15 (95% confidence interval [CI] = 0.47-2.86; p = 0.76). Infants born between 29 and 32 weeks of gestation with AKI had four-fold higher odds of moderate or severe BPD/death that remained after controlling for multiple factors (adjusted OR = 4.21, 95% CI: 2.07-8.61; p < 0.001). Conclusion Neonates born between 29 and 32 weeks who develop AKI had a higher likelihood of moderate or severe BPD/death than those without AKI. Further studies are needed to validate our findings and evaluate mechanisms of multiorgan injury.

KW - acute lung injury

KW - acute renal failure

KW - bronchopulmonary dysplasia

KW - chronic lung disease

KW - neonate

KW - organ crosstalk

KW - prematurity

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U2 - 10.1055/s-0039-3400311

DO - 10.1055/s-0039-3400311

M3 - Article

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AN - SCOPUS:85079821127

SN - 0735-1631

VL - 37

SP - 341

EP - 348

JO - American Journal of Perinatology

JF - American Journal of Perinatology

IS - 3

ER -

Acute Kidney Injury and Bronchopulmonary Dysplasia in Premature Neonates Born Less than 32 Weeks' Gestation

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