Acute eosinophilic pneumonia with intramuscular progesterone after in vitro fertilization

Objective: To report an unusual case of acute eosinophilic pneumonia that was associated with IM P in oil after IVF. Design: Case report. Setting: Academic teaching hospital. Patient(s): A 35-year-old primigravid female who developed acute eosinophilic pneumonia after administration of IM P in oil as luteal-phase support after IVF. Intervention(s): Corticosteroid therapy; replacement of IM P with intravaginal preparation. Main Outcome Measure(s): Evaluation of blood eosinophil counts along with clinical symptoms and chest radiograph findings at initial presentation and throughout the hospital course. Result(s): After the noted interventions, there was a marked improvement of clinical symptoms, chest radiograph findings, and eosinophilia. Conclusion(s): Although allergic reactions to IM P-in-oil administration are exceedingly rare, clinicians caring for patients using these products should be aware of potential adverse reactions and subsequent management.