Activation of Akt/protein kinase B overcomes a G₂/M cell cycle checkpoint induced by DNA damage

Keyphrases

• DNA Damage 100%
• Protein Kinase B 100%
• G2/M Cell Cycle Checkpoint 100%
• Mouse Embryonic Fibroblasts 66%
• Overexpression 66%
• B-cell Lymphoma 2 (Bcl-2) 66%
• Embryonic Stem Cells 66%
• Apoptosis 66%
• Mismatch Repair 66%
• G1 Phase 66%
• Human Cancer 66%
• Phosphoinositol 3-kinase 66%
• Wild Mice 33%
• HEK293 Cells 33%
• Akt Activation 33%
• Reintroduction 33%
• Null Mice 33%
• P53 Status 33%
• Mitotic Index 33%
• Activity Index 33%
• G2-M Transition 33%
• Genomic Instability 33%
• Cdc2 33%
• Anti-apoptotic 33%
• Active Form 33%
• Herpes Simplex Virus Thymidine Kinase 33%
• Thymidine Kinase Gene 33%
• Mutagens 33%
• Constitutively Active 33%
• Cell Cycle Checkpoint 33%
• G2 Arrest 33%
• DNA Mismatch Repair 33%
• Continuous Exposure 33%
• Akt Kinase 33%
• Missing Components 33%
• PTEN-null 33%

Immunology and Microbiology

• DNA Damage 100%
• Cell Cycle Checkpoint 100%
• Phosphotransferase 100%
• Kinase 100%
• Mismatch Repair 40%
• Bcl-2 40%
• Cell Cycle 40%
• Embryonic Stem Cell 40%
• Cell Cycle G1 Phase 40%
• Fibroblast 40%
• Programmed Cell Death 40%
• Wild Type 20%
• P53 20%
• Knockout Mouse 20%
• Wild Type Mouse 20%
• Mismatch DNA Repair 20%
• Herpes Simplex Virus 20%
• Genomic Instability 20%
• G2 Phase Cell Cycle Checkpoint 20%
• Mitosis Index 20%

Biochemistry, Genetics and Molecular Biology

• DNA Damage 100%
• Protein Kinase B 100%
• Cell Cycle Checkpoint 100%
• DNA Mismatch Repair 33%
• Kinase 22%
• Phosphotransferase 22%
• Cell Cycle 22%
• Embryonic Stem Cell 22%
• Bcl-2 22%
• G1 Phase 22%
• Fibroblast 22%
• Programmed Cell Death 22%
• Inositol Phosphate 22%
• Wild Type 11%
• P53 11%
• Wild Type Mouse 11%
• Knockout Mouse 11%
• Herpes Simplex Virus 11%
• Thymidine Kinase 11%
• Myc 11%
• G2 Phase Cell Cycle Checkpoint 11%
• Mitosis Index 11%
• Genomic Instability 11%