@article{218dd70867c14db5aac4e1afe43fb722,
title = "Actigraphic sleep patterns and cognitive decline in the Hispanic Community Health Study/Study of Latinos",
abstract = "Introduction: We determined if actigraphy-derived sleep patterns led to 7-year cognitive decline in middle-aged to older Hispanic/Latino adults. Methods: We examined 1035 adults, 45 to 64 years of age, from the Hispanic Community Health Study/Study of Latinos. Participants had repeated measures of cognitive function 7 years apart, home sleep apnea studies, and 1 week of actigraphy. Survey linear regression evaluated prospective associations between sleep and cognitive change, adjusting for main covariates. Results: Longer sleep-onset latency was associated with declines in global cognitive function, verbal learning, and verbal memory. Longer sleep-onset latency was also cross-sectionally associated with verbal learning, verbal memory, and word fluency. Sleep fragmentation was not associated with cognitive change. Conclusion: In a cohort of mostly middle-aged Hispanic/Latinos, actigraphy-derived sleep-onset latency predicted 7-year cognitive change. These findings may serve as targets for sleep interventions of cognitive decline.",
keywords = "Hispanic/Latinos, actigraphy, cognitive decline, cohort studies, risk factors in epidemiology, sleep",
author = "Christian Agudelo and Wassim Tarraf and Benson Wu and Wallace, {Douglas M.} and Patel, {Sanjay R.} and Susan Redline and Sonya Kaur and Martha Daviglus and Zee, {Phyllis C.} and Guido Simonelli and Yasmin Mossavar-Rahmani and Daniela Sotres-Alvarez and Donglin Zeng and Gallo, {Linda C.} and Gonz{\'a}lez, {Hector M.} and Ramos, {Alberto R.}",
note = "Funding Information: This work is supported by National Institute on Aging (R01AG048642, RF1AG054548, RF1AG061022, and R21AG056952) and by the National Heart Lung Blood Institute (R01HL098297). Dr. Ramos receive additional support from R21HL140437. The Hispanic Community Health Study/Study of Latinos was carried out as a collaborative study supported by contracts from the National Heart, Lung, and Blood Institute (NHLBI) to the University of North Carolina (N01-HC65233), University of Miami (N01-HC65234), Albert Einstein College of Medicine (N01-HC65235), Northwestern University (N01-HC65236), and San Diego State University (N01-HC65237). The following Institutes/Centers/Offices contribute to the HCHS/SOL through a transfer of funds to the NHLBI: National Institute on Minority Health and Health Disparities, National Institute on Deafness and Other Communication Disorders, National Institute of Dental and Craniofacial Research, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, NIH Institution-Office of Dietary Supplements. Funding Information: This work is supported by National Institute on Aging (R01AG048642, RF1AG054548, RF1AG061022, and R21AG056952) and by the National Heart Lung Blood Institute (R01HL098297). Dr. Ramos receive additional support from R21HL140437. The Hispanic Community Health Study/Study of Latinos was carried out as a collaborative study supported by contracts from the National Heart, Lung, and Blood Institute (NHLBI) to the University of North Carolina (N01‐HC65233), University of Miami (N01‐HC65234), Albert Einstein College of Medicine (N01‐HC65235), Northwestern University (N01‐HC65236), and San Diego State University (N01‐HC65237). The following Institutes/Centers/Offices contribute to the HCHS/SOL through a transfer of funds to the NHLBI: National Institute on Minority Health and Health Disparities, National Institute on Deafness and Other Communication Disorders, National Institute of Dental and Craniofacial Research, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, NIH Institution‐Office of Dietary Supplements. Publisher Copyright: {\textcopyright} 2020 the Alzheimer's Association",
year = "2021",
month = jun,
doi = "10.1002/alz.12250",
language = "English (US)",
volume = "17",
pages = "959--968",
journal = "Alzheimer's and Dementia",
issn = "1552-5260",
publisher = "Elsevier Inc.",
number = "6",
}
