S. Caito, L. G. Costa, L. U. Rongzhu, Michael Aschner

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Acrylonitrile is a colorless chemical mainly produced by the ammoxidation of propylene used as a raw material in the manufacture of plastics, resins, and nitriles. Exposure to acrylonitrile has been shown to cause death and neurological dysfunction partly similar to cyanide poisoning. In this article, authors review the sources of acrylonitrile exposure, metabolism, and elimination in humans, as well as its neurological effects and underlying mechanisms of its toxicity.

Original languageEnglish (US)
Title of host publicationEncyclopedia of the Neurological Sciences
PublisherElsevier Inc.
Number of pages3
ISBN (Electronic)9780123851574
ISBN (Print)9780123851581
StatePublished - Jan 1 2014


  • 2-Cyanoethylene
  • Cyanide
  • Cytochrome P450 CYP2E1
  • Glutathione conjugate
  • Glutathione depletion
  • Glutathione S-transferase
  • Industrial chemicals
  • Neurotoxicology
  • Oxidative stress
  • Plastics

ASJC Scopus subject areas

  • Medicine(all)


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