Acrylamide and Related α,β-Unsaturated Carbonyl Derivatives

R. M. LoPachin, T. Gavin

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Acrylamide is a weak electrophile and a member of a large class of structurally related type-2 alkenes that includes acrolein and other well-known toxicants. Human exposure occurs through occupation, pollution, diet, and cigarette smoking and can result in mental status changes, ataxia, and skeletal muscle weakness. Acrylamide neurotoxicity appears to be mediated by early nerve terminal dysfunction in the peripheral and central nervous systems. Although the precise mechanism is unknown, acrylamide can inhibit presynaptic protein function by forming covalent bonds (adducts) with sulfhydryl thiolate groups on corresponding cysteine residues. Some evidence also suggests that acrylamide is a developmental toxicant and a possible carcinogen.

Original languageEnglish (US)
Title of host publicationEncyclopedia of the Neurological Sciences
PublisherElsevier Inc.
Number of pages4
ISBN (Electronic)9780123851574
ISBN (Print)9780123851581
StatePublished - Jan 1 2014


  • Distal axonopathy
  • Electrophile
  • Environmental pollution
  • Nerve terminal
  • Neurotoxicant
  • Toxic neuropathy
  • Type-2 alkenes
  • α,β-Unsaturated carbonyl derivatives

ASJC Scopus subject areas

  • General Medicine


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