Ablative therapies in Barrett's esophagus

Audrey C. Pendleton, W. Scott Melvin

Research output: Chapter in Book/Report/Conference proceedingChapter


Barrett's esophagus (BE) is a condition in which the stratified squamous epithelium that normally lines the distal esophagus lumen is replaced by metaplastic columnar epithelium that has both gastric and intestinal features. It is usually caused by persistent damage to the esophageal mucosa due to long-standing gastroesophageal reflux disease (GERD) and predisposes patients to esophageal adenocarcinoma (EAC), a cancer with a significantly increasing incidence over the past 40 years. While there are several risk factors for EAC, including smoking and obesity, GERD is the most significant one. Patients with BE have an estimated 30-125-fold greater chance of developing EAC compared to the general population.

Original languageEnglish (US)
Title of host publicationBenign Esophageal Disease
Subtitle of host publicationModern Surgical Approaches and Techniques
Number of pages7
ISBN (Electronic)9783030514891
ISBN (Print)9783030514884
StatePublished - Apr 12 2021


  • Ablation
  • Barrett
  • Cancer
  • Esophagus

ASJC Scopus subject areas

  • General Medicine


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