Ablation for atrial fibrillation: Termination of atrial fibrillation is not the end point

Pasquale Santangeli, Luigi Di Biase, Amin Al-Ahmad, Rodney Horton, J. David Burkhardt, Javier E. Sanchez, Rong Bai, Agnes Pump, Sanghamitra Mohanty, Andrea Natale

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


Permanent pulmonary vein isolation constitutes the main procedural goal of current approaches to atrial fibrillation (AF) catheter ablation, with established effectiveness as a stand-alone procedure in most patients with paroxysmal AF. In patients with AF of longer duration, however, the definition of the optimal procedural end point is still controversial. Based on analysis of data from 16 studies that have assessed the value of AF termination in predicting long-term procedural success, it is concluded that AF termination clearly represents an unreliable procedural end point during ablation of nonparoxysmal AF.

Original languageEnglish (US)
Pages (from-to)343-352
Number of pages10
JournalCardiac Electrophysiology Clinics
Issue number3
StatePublished - Sep 2012
Externally publishedYes


  • Catheter ablation
  • Nonparoxysmal atrial fibrillation
  • Procedural end point
  • Pulmonary vein isolation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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