TY - JOUR
T1 - A topography of executive functions and their interactions revealed by functional magnetic resonance imaging
AU - Fassbender, C.
AU - Murphy, K.
AU - Foxe, J. J.
AU - Wylie, G. R.
AU - Javitt, D. C.
AU - Robertson, I. H.
AU - Garavan, H.
N1 - Funding Information:
This research was supported by USPHS grants DA14100-01, GCRC M01 RR00058, NIMH grants MH63434, MH65350, the Irish Research Council for the Humanities and Social Sciences and the James McDonnell Foundation. The assistance of Deirdre Foxe, Patrick O'Donnell and Andrea Kübler is also gratefully acknowledged.
PY - 2004/7
Y1 - 2004/7
N2 - We used fMRI to study the brain processes involved in the executive control of behavior. The Sustained Attention to Response Task (SART), which allows unpredictable and predictable NOGO events to be contrasted, was imaged using a mixed (block and event-related) fMRI design to examine tonic and phasic processes involved in response inhibition, error detection, conflict monitoring and sustained attention. A network of regions, including right ventral prefrontal cortex (PFC), left dorsolateral PFC (DLPFC) and right inferior parietal cortex, was activated for successful unpredictable inhibitions, while rostral anterior cingulate was implicated in error processing and the pre-SMA in conflict monitoring. Furthermore, the pattern of correlations between left dorsolateral PFC, implicated in task-set maintenance, and the pre-SMA were indicative of a tight coupling between prefrontally mediated control and conflict levels monitored more posteriorly. The results reveal that the executive control of behavior can be separated into distinct functions performed by discrete cortical regions.
AB - We used fMRI to study the brain processes involved in the executive control of behavior. The Sustained Attention to Response Task (SART), which allows unpredictable and predictable NOGO events to be contrasted, was imaged using a mixed (block and event-related) fMRI design to examine tonic and phasic processes involved in response inhibition, error detection, conflict monitoring and sustained attention. A network of regions, including right ventral prefrontal cortex (PFC), left dorsolateral PFC (DLPFC) and right inferior parietal cortex, was activated for successful unpredictable inhibitions, while rostral anterior cingulate was implicated in error processing and the pre-SMA in conflict monitoring. Furthermore, the pattern of correlations between left dorsolateral PFC, implicated in task-set maintenance, and the pre-SMA were indicative of a tight coupling between prefrontally mediated control and conflict levels monitored more posteriorly. The results reveal that the executive control of behavior can be separated into distinct functions performed by discrete cortical regions.
KW - Anterior cingulate cortex
KW - Attentional control
KW - Cognition
KW - Dorsolateral prefrontal cortex
KW - Functional MRI
KW - Neural basis of behavior
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U2 - 10.1016/j.cogbrainres.2004.02.007
DO - 10.1016/j.cogbrainres.2004.02.007
M3 - Article
C2 - 15183386
AN - SCOPUS:2942585111
SN - 0926-6410
VL - 20
SP - 132
EP - 143
JO - Cognitive Brain Research
JF - Cognitive Brain Research
IS - 2
ER -