TY - JOUR
T1 - A systematic review on the metabolic effects of chlorpyrifos
AU - Farkhondeh, Tahereh
AU - Mehrpour, Omid
AU - Sadeghi, Mahmood
AU - Aschner, Michael
AU - Aramjoo, Hamed
AU - Roshanravan, Babak
AU - Samarghandian, Saeed
N1 - Publisher Copyright:
© 2021 Walter de Gruyter GmbH, Berlin/Boston.
PY - 2022/3/1
Y1 - 2022/3/1
N2 - Organophosphate (OP) pesticides, including chlorpyrifos (CPF), can alter metabolic hemostasis. The current systematic study investigated blood glucose, lipid profiles, and body weight alterations in rodents and fish exposed to CPF. The systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) Guidelines, querying online databases, including Web of Science, PubMed, and Scopus and also search engine including Google Scholar, through January 2021. Studies on rodent and fish exposed to CPF assessing metabolic functions were selected. All studies were in the English language, with other languages being excluded from the review. Two investigators independently assessed each of the articles. The first author's name, publication date, animal model, age, sample size, gender, dose, duration, and route of exposure and outcomes were extracted from each publication. The present review summarizes findings from 61 publications on glycemic, lipid profile, insulin, and body weight changes in rodents and fish exposed to CPF exposure. Most of the studies reported hyperglycemia, hyperlipidemia, and decreased insulin levels and body weight following exposure to CPF. Additionally, we confirmed that the CPF-induced metabolic alterations were both dose- and time-dependent. Our findings support an association between CPF exposure and metabolic diseases. However, more studies are needed to identify the metabolic-disrupting effects of CPF and their underlying mechanisms.
AB - Organophosphate (OP) pesticides, including chlorpyrifos (CPF), can alter metabolic hemostasis. The current systematic study investigated blood glucose, lipid profiles, and body weight alterations in rodents and fish exposed to CPF. The systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) Guidelines, querying online databases, including Web of Science, PubMed, and Scopus and also search engine including Google Scholar, through January 2021. Studies on rodent and fish exposed to CPF assessing metabolic functions were selected. All studies were in the English language, with other languages being excluded from the review. Two investigators independently assessed each of the articles. The first author's name, publication date, animal model, age, sample size, gender, dose, duration, and route of exposure and outcomes were extracted from each publication. The present review summarizes findings from 61 publications on glycemic, lipid profile, insulin, and body weight changes in rodents and fish exposed to CPF exposure. Most of the studies reported hyperglycemia, hyperlipidemia, and decreased insulin levels and body weight following exposure to CPF. Additionally, we confirmed that the CPF-induced metabolic alterations were both dose- and time-dependent. Our findings support an association between CPF exposure and metabolic diseases. However, more studies are needed to identify the metabolic-disrupting effects of CPF and their underlying mechanisms.
KW - animal model
KW - blood glucose
KW - body weight
KW - chlorpyrifos
KW - fish
KW - insulin
KW - lipid profile
KW - rodent
UR - http://www.scopus.com/inward/record.url?scp=85106374078&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85106374078&partnerID=8YFLogxK
U2 - 10.1515/reveh-2020-0150
DO - 10.1515/reveh-2020-0150
M3 - Review article
C2 - 33962508
AN - SCOPUS:85106374078
SN - 0048-7554
VL - 37
SP - 137
EP - 151
JO - Reviews on Environmental Health
JF - Reviews on Environmental Health
IS - 1
ER -