A single in-vivo exposure to Δ9THC blocks endocannabinoid-mediated synaptic plasticity

Susana Mato; Vivien Chevaleyre; David Robbe; Angel Pazos; Pablo E. Castillo; Olivier J. Manzoni

doi:10.1038/nn1251

A single in-vivo exposure to Δ9THC blocks endocannabinoid-mediated synaptic plasticity

Susana Mato, Vivien Chevaleyre, David Robbe, Angel Pazos, Pablo E. Castillo, Olivier J. Manzoni

Neuroscience

Research output: Contribution to journal › Article › peer-review

191 Scopus citations

Abstract

Endogenous cannabinoids (eCB) mediate synaptic plasticity in brain regions involved in learning and reward. Here we show that in mice, a single in-vivo exposure to Δ9-tetrahydrocannabinol (THC) abolishes the retrograde signaling that underlies eCB-mediated synaptic plasticity in both nucleus accumbens (NAc) and hippocampus in vitro. This effect is reversible within 3 days and is associated with a transient modification in the functional properties of cannabinoid receptors.

Original language	English (US)
Pages (from-to)	585-586
Number of pages	2
Journal	Nature Neuroscience
Volume	7
Issue number	6
DOIs	https://doi.org/10.1038/nn1251
State	Published - Jun 2004

ASJC Scopus subject areas

Neuroscience(all)

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AU - Castillo, Pablo E.

AU - Manzoni, Olivier J.

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A single in-vivo exposure to Δ9THC blocks endocannabinoid-mediated synaptic plasticity

Abstract

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