A Rat Model of Neonatal Candidiasis Demonstrates the Importance of Lipases as Virulence Factors for Candida albicans and Candida parapsilosis

David Trofa; Lamia Soghier; Christina Long; Joshua D. Nosanchuk; Attila Gacser; David L. Goldman

doi:10.1007/s11046-011-9429-3

A Rat Model of Neonatal Candidiasis Demonstrates the Importance of Lipases as Virulence Factors for Candida albicans and Candida parapsilosis

David Trofa, Lamia Soghier, Christina Long, Joshua D. Nosanchuk, Attila Gacser, David L. Goldman

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

The host factors that contribute to the increased susceptibility of preterm neonates to invasive candidiasis have not been fully identified. In addition, there has been a lack of suitable models to study this problem. We show that rat pups, similar to premature neonates, display increased susceptibility to experimental Candida albicans infection. Further, we find that both C. albicans and Candida parapsilosis lipase disruptant mutants exhibit decreased virulence in rat pups, demonstrating the utility of the model to evaluate the impact of specific genes in disease pathogenesis. Our findings highlight the contribution of lipases to the virulence of C. albicans and C. parapsilosis and provide a new system to study the increased susceptibility of neonates to Candida infections.

Original language	English (US)
Pages (from-to)	169-178
Number of pages	10
Journal	Mycopathologia
Volume	172
Issue number	3
DOIs	https://doi.org/10.1007/s11046-011-9429-3
State	Published - Sep 2011

Keywords

Candida
Infection model
Lipases
Rat

ASJC Scopus subject areas

Microbiology
Applied Microbiology and Biotechnology
Agronomy and Crop Science
veterinary (miscalleneous)

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10.1007/s11046-011-9429-3

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abstract = "The host factors that contribute to the increased susceptibility of preterm neonates to invasive candidiasis have not been fully identified. In addition, there has been a lack of suitable models to study this problem. We show that rat pups, similar to premature neonates, display increased susceptibility to experimental Candida albicans infection. Further, we find that both C. albicans and Candida parapsilosis lipase disruptant mutants exhibit decreased virulence in rat pups, demonstrating the utility of the model to evaluate the impact of specific genes in disease pathogenesis. Our findings highlight the contribution of lipases to the virulence of C. albicans and C. parapsilosis and provide a new system to study the increased susceptibility of neonates to Candida infections.",

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AU - Nosanchuk, Joshua D.

AU - Gacser, Attila

AU - Goldman, David L.

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A Rat Model of Neonatal Candidiasis Demonstrates the Importance of Lipases as Virulence Factors for Candida albicans and Candida parapsilosis

Abstract

Keywords

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