A pool of native alpha-chains in guinea pig reticulocytes

T. Campana, S. Pollack, R. L. Nagel

Research output: Contribution to journalArticlepeer-review


Five radioactive peaks can be identified when hemolysates prepared from 59Fe-labelled guinea pig reticlocytes are subjected to molecular sieve chromatography. The third peak, hemoglobin, is followed by another hemi-containing peak eluting with an apparent molecular weight of 17,000. We now demonstrate that this 17,000 MW peak consists of α-chains. The high specific activity (59Fe/heme) of these α-chains suggests that they may be the primary site of heme entry into the hemoglobin molecule.

Original languageEnglish (US)
Pages (from-to)190-193
Number of pages4
JournalActa Haematologica
Issue number3
StatePublished - 1982

ASJC Scopus subject areas

  • Hematology


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