Abstract
The inhibitory effects of gallium ethylenediamine-N,N,N′,N′- tetrakismethylene phosphonate [Ga(III)-EDTMP] was studied on a malignant tumor and metastatic bone lesion model induced with Walker carcinosarcoma 256 (WCS 256) in Wistar rats weighing 120 to 135 g. A water-soluble chelate, Ga(III)-EDTMP, was prepared for injection in a tumor-bearing model. Radiographic analysis at 14 days indicated that the bone invasion and osteolysis were markedly reduced in animals treated with Ga(III)-EDTMP. The calculated tumor inhibitory rates were 33.16±0.38% at a dosage of 5 mg/kg and 47.75±0.74% at 10 mg/kg. Biochemical markers such as serum calcium decreased by 23% (P<.05) and by 31% (P<.01) at dosages of 5 mg/kg and 10 mg/kg, respectively, whereas serum alkaline phosphatase (ALPase) activity decreased by 47% (P<.01) and 69% (P<.01) at the 2 dosages.
Original language | English (US) |
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Pages (from-to) | 297-306 |
Number of pages | 10 |
Journal | Advances in Therapy |
Volume | 22 |
Issue number | 4 |
DOIs | |
State | Published - Jul 2005 |
Externally published | Yes |
Keywords
- Bone metastasis
- Ga(III)-EDTMP
- Gallium ethylenediaminetetramethylene phosphonate
- Inhibitory rate
- Osteolysis
ASJC Scopus subject areas
- Pharmacology (medical)