Abstract
Affymetrix Human Gene 1.0-ST arrays were used to assess the gene expression profiles of kidney transplant patients who presented with donor-specific antibodies (DSAs) but showed normal biopsy histopathology and did not develop antibody-mediated rejection (AMR). Biopsy and whole-blood profiles for these DSA-positive, AMR-negative (DSA. +/AMR-) patients were compared to both DSA-positive, AMR-positive (DSA. +/AMR. +) patients as well as DSA-negative (DSA. -) controls. While individual gene expression changes across sample groups were relatively subtle, gene-set enrichment analysis using previously identified pathogenesis-based transcripts (PBTs) identified a clear molecular signature involving increased rejection-associated transcripts in AMR. - patients. Results from this study have been published in Kidney International (Hayde et al., 2014 [1]) and the associated data have been deposited in the GEO archive and are accessible via the following link: http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE50084.
Original language | English (US) |
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Pages (from-to) | 357-360 |
Number of pages | 4 |
Journal | Genomics Data |
Volume | 2 |
DOIs | |
State | Published - 2014 |
Keywords
- Antibody-mediated rejection
- Donor-specific antibodies
- Gene expression
- Kidney
- Transplant
ASJC Scopus subject areas
- Biotechnology
- Biochemistry
- Molecular Medicine
- Genetics