A New Quassinoid from Brucea javanica

Jun Li; Dayong Zheng; Ning Wei; Yunfeng Sun; Li Liu; Yuan Yuan; Qinghua Jiang

doi:10.1007/s10600-022-03762-2

A New Quassinoid from Brucea javanica

Jun Li, Dayong Zheng, Ning Wei, Yunfeng Sun, Li Liu, Yuan Yuan, Qinghua Jiang

Research output: Contribution to journal › Article › peer-review

Abstract

A new quassinoid, dehydrobruceantinol B (1), was isolated from the seeds of Brucea javanica, together with two known compounds, bruceantinol (2) and bruceine A (3). The structure of the new compound 1 was elucidated by advanced spectrometric methods, including HR-MS, UV, IR, 1D and 2D NMR experiments. The inhibitory effects of 1–3 on nitric oxide production in lipopolysaccharide-activated macrophages were also investigated in this study.

Original language	English (US)
Pages (from-to)	650-652
Number of pages	3
Journal	Chemistry of Natural Compounds
Volume	58
Issue number	4
DOIs	https://doi.org/10.1007/s10600-022-03762-2
State	Published - Jul 2022
Externally published	Yes

Keywords

Brucea javanica
Simaroubaceae
nitric oxide production
quassinoid

ASJC Scopus subject areas

Chemistry(all)
Biochemistry, Genetics and Molecular Biology(all)
Plant Science

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10.1007/s10600-022-03762-2

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title = "A New Quassinoid from Brucea javanica",

abstract = "A new quassinoid, dehydrobruceantinol B (1), was isolated from the seeds of Brucea javanica, together with two known compounds, bruceantinol (2) and bruceine A (3). The structure of the new compound 1 was elucidated by advanced spectrometric methods, including HR-MS, UV, IR, 1D and 2D NMR experiments. The inhibitory effects of 1–3 on nitric oxide production in lipopolysaccharide-activated macrophages were also investigated in this study.",

keywords = "Brucea javanica, Simaroubaceae, nitric oxide production, quassinoid",

author = "Jun Li and Dayong Zheng and Ning Wei and Yunfeng Sun and Li Liu and Yuan Yuan and Qinghua Jiang",

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doi = "10.1007/s10600-022-03762-2",

language = "English (US)",

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T1 - A New Quassinoid from Brucea javanica

AU - Li, Jun

AU - Zheng, Dayong

AU - Wei, Ning

AU - Sun, Yunfeng

AU - Liu, Li

AU - Yuan, Yuan

AU - Jiang, Qinghua

N1 - Funding Information: This study is supported by the Department of Science and Technology of Liaoning Province (2020-MS-225). Publisher Copyright: © 2022, Springer Science+Business Media, LLC, part of Springer Nature.

PY - 2022/7

Y1 - 2022/7

N2 - A new quassinoid, dehydrobruceantinol B (1), was isolated from the seeds of Brucea javanica, together with two known compounds, bruceantinol (2) and bruceine A (3). The structure of the new compound 1 was elucidated by advanced spectrometric methods, including HR-MS, UV, IR, 1D and 2D NMR experiments. The inhibitory effects of 1–3 on nitric oxide production in lipopolysaccharide-activated macrophages were also investigated in this study.

AB - A new quassinoid, dehydrobruceantinol B (1), was isolated from the seeds of Brucea javanica, together with two known compounds, bruceantinol (2) and bruceine A (3). The structure of the new compound 1 was elucidated by advanced spectrometric methods, including HR-MS, UV, IR, 1D and 2D NMR experiments. The inhibitory effects of 1–3 on nitric oxide production in lipopolysaccharide-activated macrophages were also investigated in this study.

KW - Brucea javanica

KW - Simaroubaceae

KW - nitric oxide production

KW - quassinoid

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JF - Chemistry of Natural Compounds

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ER -

A New Quassinoid from Brucea javanica

Abstract

Keywords

ASJC Scopus subject areas

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