TY - JOUR
T1 - A mouse model of human familial adenomatous polyposis
AU - Yang, Kan
AU - Edelmann, Winfried
AU - Fan, Kunhua
AU - Lau, Kirkland
AU - Kolli, Venkateswara R.
AU - Fodde, Riccardo
AU - Khan, P. Meera
AU - Kucherlapati, Raju
AU - Lipkin, Martin
PY - 1997/2/15
Y1 - 1997/2/15
N2 - In an effort to generate a good mouse model for human colorectal cancer, we generated mice which carry a mutation in the adenomatous polyposis coli (Apc) gene. Mice which are heterozygous for the mutation, designated Apc1638, develop colonic polyps and tumors of the small intestine. Neoplasms were found in 96% of animals studied, and they included adenomas, adenocarcinomas, and polypoid hyperplasias. The mice developed an average of 3.3 tumors, with the highest number in duodenum, followed by jejunum, stomach, ileum, and colon. Focal areas of dysplasias were observed in the colonic mucosa in 50% of mice which were 10 months old or older. These results suggest that mice carrying the Apc1638 mutation can serve as a good model to study the initiation, progression, and inhibition of gastrointestinal tumors.
AB - In an effort to generate a good mouse model for human colorectal cancer, we generated mice which carry a mutation in the adenomatous polyposis coli (Apc) gene. Mice which are heterozygous for the mutation, designated Apc1638, develop colonic polyps and tumors of the small intestine. Neoplasms were found in 96% of animals studied, and they included adenomas, adenocarcinomas, and polypoid hyperplasias. The mice developed an average of 3.3 tumors, with the highest number in duodenum, followed by jejunum, stomach, ileum, and colon. Focal areas of dysplasias were observed in the colonic mucosa in 50% of mice which were 10 months old or older. These results suggest that mice carrying the Apc1638 mutation can serve as a good model to study the initiation, progression, and inhibition of gastrointestinal tumors.
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U2 - 10.1002/(SICI)1097-010X(19970215)277:3<245::AID-JEZ5>3.0.CO;2-O
DO - 10.1002/(SICI)1097-010X(19970215)277:3<245::AID-JEZ5>3.0.CO;2-O
M3 - Article
C2 - 9062998
AN - SCOPUS:0031568788
SN - 0022-104X
VL - 277
SP - 245
EP - 254
JO - Journal of Experimental Zoology
JF - Journal of Experimental Zoology
IS - 3
ER -