A model for transcription termination by RNA polymerase I

Walter H. Lang, Bernice E. Morrow, Qida Ju, Jonathan R. Warner, Ronald H. Reeder

Research output: Contribution to journalArticlepeer-review

83 Scopus citations


The transcription termination site for yeast RNA polymerase I requires not only an 11 bp binding site for Reb1p, but also about 46 bp of 5′ flanking sequence. We propose that Reb1p bound to its site is part of a pause element, while the 5′ flanking sequence contains a release element. Pausing requires little other than the DNA-binding domain of Reb1p and is not specific for polymerase I. The release element, however, can be polymerase specific. We propose a general model for eukaryotic transcription terminators in which termination occurs when a relatively nonspecific signal induces polymerase to pause in the context of a release element.

Original languageEnglish (US)
Pages (from-to)527-534
Number of pages8
Issue number3
StatePublished - Nov 4 1994

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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