TY - JOUR
T1 - A guide to fragile sites on human chromosomes
AU - Hecht, Frederick
AU - Ramesh, K. H.
AU - Lockwood, David H.
N1 - Funding Information:
This work was supported by Program Project CA-41124 from the National Cancer Institute, and additionally by the Southwest Biomedical Research Institute.
PY - 1990/1
Y1 - 1990/1
N2 - This is a guide to 107 fragile sites, all those considered at the most recent International Workshop on Human Gene Mapping, HGM 9.5, held in 1988. The chromosome band locations of all 107 fragile sites are given, together with their gene symbols, frequency, mode of induction, and status. The majority of these fragile sites are common ones induced to expression by aphidicolin. Fragile sites are nonrandomly distributed within the genome. Chromosome 3 is especially short of known fragile sites. Chromosome 21, the chromosome triplicated in Down syndrome, has no known fragile sites.
AB - This is a guide to 107 fragile sites, all those considered at the most recent International Workshop on Human Gene Mapping, HGM 9.5, held in 1988. The chromosome band locations of all 107 fragile sites are given, together with their gene symbols, frequency, mode of induction, and status. The majority of these fragile sites are common ones induced to expression by aphidicolin. Fragile sites are nonrandomly distributed within the genome. Chromosome 3 is especially short of known fragile sites. Chromosome 21, the chromosome triplicated in Down syndrome, has no known fragile sites.
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U2 - 10.1016/0165-4608(90)90195-G
DO - 10.1016/0165-4608(90)90195-G
M3 - Article
C2 - 2104573
AN - SCOPUS:0025022409
SN - 0165-4608
VL - 44
SP - 37
EP - 45
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 1
ER -
