A distinct coagulopathy associated with interleukin-2 therapy

L. Oleksowicz, M. Strack, J. P. Dutcher, I. Sussman, G. Caliendo, J. Sparano, P. H. Wiernik

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


We studied the coagulation profiles of 14 patients with advanced malignancies treated with Interleukin-2 (IL- 2). A 43% prolongation of the PTT (P < 0 .001) and a significant decrease in functional levels of factors II, IX, X, XI, and XII were observed 6 h post IL- 2 treatment in comparison to pretreatment values. These parameters normalized within 2-3 d following IL-2 administration. The PT, factors V, VII VIII, fibrinogen and D-dimer levels were unchanged with IL-2 treatment. This pattern of coagulopathy has not previously been reported.

Original languageEnglish (US)
Pages (from-to)892-894
Number of pages3
JournalBritish Journal of Haematology
Issue number4
StatePublished - 1994
Externally publishedYes


  • Coagulopathy
  • IL-2
  • Malignancy

ASJC Scopus subject areas

  • Hematology


Dive into the research topics of 'A distinct coagulopathy associated with interleukin-2 therapy'. Together they form a unique fingerprint.

Cite this