A comparative immunohistochemical study on striatal Met-enkephalin expression in Alzheimer's disease and in progressive supranuclear palsy

S. Matsumoto; S. Goto; A. Hirano

doi:10.1007/BF00662640

A comparative immunohistochemical study on striatal Met-enkephalin expression in Alzheimer's disease and in progressive supranuclear palsy

S. Matsumoto, S. Goto, A. Hirano

Pathology

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6 Scopus citations

Abstract

Using a sensitive immunoperoxidase technique we examined Met-enkephalin (MEnk) expression in the striatum and globus pallidus external segment (GPe) from patients with Alzheimer's disease (AD) and with progressive supranuclear palsy (PSP). In AD patients strong MEnk-like immunoreactivity was persistent in the striatum showing so-called "striosomes". In addition, a number of typical "woolly fibers" were observed in the GPe. MEnk-positive striosomes were also visible in the striatum of PSP patients and were similar to those of normal controls and of AD patients. However, the MEnk-positive "woolly fibers" appcarance was less well recognizable in the GPe from all the PSP patients examined.

Original language	English (US)
Pages (from-to)	74-77
Number of pages	4
Journal	Acta Neuropathologica
Volume	81
Issue number	1
DOIs	https://doi.org/10.1007/BF00662640
State	Published - Jan 1 1990

Keywords

Alzheimer's disease
Globus pallidus
Met-Enkephalin
Progressive supranuclear palsy
Striatum

ASJC Scopus subject areas

Pathology and Forensic Medicine
Clinical Neurology
Cellular and Molecular Neuroscience

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10.1007/BF00662640

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abstract = "Using a sensitive immunoperoxidase technique we examined Met-enkephalin (MEnk) expression in the striatum and globus pallidus external segment (GPe) from patients with Alzheimer's disease (AD) and with progressive supranuclear palsy (PSP). In AD patients strong MEnk-like immunoreactivity was persistent in the striatum showing so-called {"}striosomes{"}. In addition, a number of typical {"}woolly fibers{"} were observed in the GPe. MEnk-positive striosomes were also visible in the striatum of PSP patients and were similar to those of normal controls and of AD patients. However, the MEnk-positive {"}woolly fibers{"} appcarance was less well recognizable in the GPe from all the PSP patients examined.",

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AU - Goto, S.

AU - Hirano, A.

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N2 - Using a sensitive immunoperoxidase technique we examined Met-enkephalin (MEnk) expression in the striatum and globus pallidus external segment (GPe) from patients with Alzheimer's disease (AD) and with progressive supranuclear palsy (PSP). In AD patients strong MEnk-like immunoreactivity was persistent in the striatum showing so-called "striosomes". In addition, a number of typical "woolly fibers" were observed in the GPe. MEnk-positive striosomes were also visible in the striatum of PSP patients and were similar to those of normal controls and of AD patients. However, the MEnk-positive "woolly fibers" appcarance was less well recognizable in the GPe from all the PSP patients examined.

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KW - Progressive supranuclear palsy

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A comparative immunohistochemical study on striatal Met-enkephalin expression in Alzheimer's disease and in progressive supranuclear palsy

Abstract

Keywords

ASJC Scopus subject areas

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