A C. elegans CLIC-like Protein Required for Intracellular Tube Formation and Maintenance

Katherine L. Berry; Hannes E. Bülow; David H. Hall; Oliver Hobert

doi:10.1126/science.1087667

A C. elegans CLIC-like Protein Required for Intracellular Tube Formation and Maintenance

Katherine L. Berry, Hannes E. Bülow, David H. Hall, Oliver Hobert

Neuroscience

Research output: Contribution to journal › Article › peer-review

128 Scopus citations

Abstract

The Caenorhabditis elegans excretory canal is composed of a single elongated and branched cell that is tunneled by an inner lumen of apical character. Loss of the exc-4 gene causes a cystic enlargement of this intracellular tube. exc-4 encodes a member of the chloride intracellular channel (CLIC) family of proteins. EXC-4 protein localizes to various tubular membranes in distinct cell types, including the lumenal membrane of the excretory tubes. A conserved 55-amino acid domain enables EXC-4 translocation from the cytosol to the lumenal membrane. The tubular architecture of this membrane requires EXC-4 for both its formation and maintenance.

Original language	English (US)
Pages (from-to)	2134-2137
Number of pages	4
Journal	Science
Volume	302
Issue number	5653
DOIs	https://doi.org/10.1126/science.1087667
State	Published - Dec 19 2003

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abstract = "The Caenorhabditis elegans excretory canal is composed of a single elongated and branched cell that is tunneled by an inner lumen of apical character. Loss of the exc-4 gene causes a cystic enlargement of this intracellular tube. exc-4 encodes a member of the chloride intracellular channel (CLIC) family of proteins. EXC-4 protein localizes to various tubular membranes in distinct cell types, including the lumenal membrane of the excretory tubes. A conserved 55-amino acid domain enables EXC-4 translocation from the cytosol to the lumenal membrane. The tubular architecture of this membrane requires EXC-4 for both its formation and maintenance.",

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AU - Berry, Katherine L.

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AU - Hall, David H.

AU - Hobert, Oliver

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AB - The Caenorhabditis elegans excretory canal is composed of a single elongated and branched cell that is tunneled by an inner lumen of apical character. Loss of the exc-4 gene causes a cystic enlargement of this intracellular tube. exc-4 encodes a member of the chloride intracellular channel (CLIC) family of proteins. EXC-4 protein localizes to various tubular membranes in distinct cell types, including the lumenal membrane of the excretory tubes. A conserved 55-amino acid domain enables EXC-4 translocation from the cytosol to the lumenal membrane. The tubular architecture of this membrane requires EXC-4 for both its formation and maintenance.

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A C. elegans CLIC-like Protein Required for Intracellular Tube Formation and Maintenance

Abstract

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