A brain-based definition of death and criteria for its determination after arrest of circulation or neurologic function in Canada: a 2023 clinical practice guideline

Sam D. Shemie; Lindsay C. Wilson; Laura Hornby; John Basmaji; Andrew J. Baker; Cécile M. Bensimon; Jennifer A. Chandler; Michaël Chassé; Rosanne Dawson; Sonny Dhanani; Owen T. Mooney; Aimee J. Sarti; Christy Simpson; Jeanne Teitelbaum; Sylvia Torrance; J. Gordon Boyd; Joanne Brennan; Heather Brewster; Robert Carignan; Kirk J. Dawe; Christopher J. Doig; Kennedy Elliott-Pohl; Teneille E. Gofton; Michael Hartwick; Andrew Healey; Kimia Honarmand; Karen Hornby; George Isac; Aly Kanji; Joann Kawchuk; Jennifer A. Klowak; Andreas H. Kramer; Julie Kromm; Allana E. LeBlanc; Katarina Lee-Ameduri; Laurie A. Lee; Murdoch Leeies; Ariane Lewis; Alex Manara; Shauna Matheson; Nicole K.A. McKinnon; Nicholas Murphy; Joel Neves Briard; Thaddeus M. Pope; Mypinder S. Sekhon; Jai Jai S. Shanker; Gurmeet Singh; Jeffrey Singh; Marat Slessarev; Karim Soliman; Stephanie Sutherland; Matthew J. Weiss; Randi Zlotnik Shaul; Lionel S. Zuckier; David J. Zorko; Bram Rochwerg

doi:10.1007/s12630-023-02431-4

A brain-based definition of death and criteria for its determination after arrest of circulation or neurologic function in Canada: a 2023 clinical practice guideline

Sam D. Shemie, Lindsay C. Wilson, Laura Hornby, John Basmaji, Andrew J. Baker, Cécile M. Bensimon, Jennifer A. Chandler, Michaël Chassé, Rosanne Dawson, Sonny Dhanani, Owen T. Mooney, Aimee J. Sarti, Christy Simpson, Jeanne Teitelbaum, Sylvia Torrance, J. Gordon Boyd, Joanne Brennan, Heather Brewster, Robert Carignan, Kirk J. DaweChristopher J. Doig, Kennedy Elliott-Pohl, Teneille E. Gofton, Michael Hartwick, Andrew Healey, Kimia Honarmand, Karen Hornby, George Isac, Aly Kanji, Joann Kawchuk, Jennifer A. Klowak, Andreas H. Kramer, Julie Kromm, Allana E. LeBlanc, Katarina Lee-Ameduri, Laurie A. Lee, Murdoch Leeies, Ariane Lewis, Alex Manara, Shauna Matheson, Nicole K.A. McKinnon, Nicholas Murphy, Joel Neves Briard, Thaddeus M. Pope, Mypinder S. Sekhon, Jai Jai S. Shanker, Gurmeet Singh, Jeffrey Singh, Marat Slessarev, Karim Soliman, Stephanie Sutherland, Matthew J. Weiss, Randi Zlotnik Shaul, Lionel S. Zuckier, David J. Zorko, Bram Rochwerg

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

This 2023 Clinical Practice Guideline provides the biomedical definition of death based on permanent cessation of brain function that applies to all persons, as well as recommendations for death determination by circulatory criteria for potential organ donors and death determination by neurologic criteria for all mechanically ventilated patients regardless of organ donation potential. This Guideline is endorsed by the Canadian Critical Care Society, the Canadian Medical Association, the Canadian Association of Critical Care Nurses, Canadian Anesthesiologists’ Society, the Canadian Neurological Sciences Federation (representing the Canadian Neurological Society, Canadian Neurosurgical Society, Canadian Society of Clinical Neurophysiologists, Canadian Association of Child Neurology, Canadian Society of Neuroradiology, and Canadian Stroke Consortium), Canadian Blood Services, the Canadian Donation and Transplantation Research Program, the Canadian Association of Emergency Physicians, the Nurse Practitioners Association of Canada, and the Canadian Cardiovascular Critical Care Society.

Original language	English (US)
Pages (from-to)	483-557
Number of pages	75
Journal	Canadian Journal of Anesthesia
Volume	70
Issue number	4
DOIs	https://doi.org/10.1007/s12630-023-02431-4
State	Published - Apr 2023
Externally published	Yes

Keywords

brain death
circulatory death
death
deceased organ donation
definition of death
neurologic death

ASJC Scopus subject areas

Anesthesiology and Pain Medicine

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10.1007/s12630-023-02431-4

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Shemie, S. D., Wilson, L. C., Hornby, L., Basmaji, J., Baker, A. J., Bensimon, C. M., Chandler, J. A., Chassé, M., Dawson, R., Dhanani, S., Mooney, O. T., Sarti, A. J., Simpson, C., Teitelbaum, J., Torrance, S., Boyd, J. G., Brennan, J., Brewster, H., Carignan, R., ... Rochwerg, B. (2023). A brain-based definition of death and criteria for its determination after arrest of circulation or neurologic function in Canada: a 2023 clinical practice guideline. Canadian Journal of Anesthesia, 70(4), 483-557. https://doi.org/10.1007/s12630-023-02431-4

Shemie, SD, Wilson, LC, Hornby, L, Basmaji, J, Baker, AJ, Bensimon, CM, Chandler, JA, Chassé, M, Dawson, R, Dhanani, S, Mooney, OT, Sarti, AJ, Simpson, C, Teitelbaum, J, Torrance, S, Boyd, JG, Brennan, J, Brewster, H, Carignan, R, Dawe, KJ, Doig, CJ, Elliott-Pohl, K, Gofton, TE, Hartwick, M, Healey, A, Honarmand, K, Hornby, K, Isac, G, Kanji, A, Kawchuk, J, Klowak, JA, Kramer, AH, Kromm, J, LeBlanc, AE, Lee-Ameduri, K, Lee, LA, Leeies, M, Lewis, A, Manara, A, Matheson, S, McKinnon, NKA, Murphy, N, Briard, JN, Pope, TM, Sekhon, MS, Shanker, JJS, Singh, G, Singh, J, Slessarev, M, Soliman, K, Sutherland, S, Weiss, MJ, Shaul, RZ, Zuckier, LS, Zorko, DJ & Rochwerg, B 2023, 'A brain-based definition of death and criteria for its determination after arrest of circulation or neurologic function in Canada: a 2023 clinical practice guideline', Canadian Journal of Anesthesia, vol. 70, no. 4, pp. 483-557. https://doi.org/10.1007/s12630-023-02431-4

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abstract = "This 2023 Clinical Practice Guideline provides the biomedical definition of death based on permanent cessation of brain function that applies to all persons, as well as recommendations for death determination by circulatory criteria for potential organ donors and death determination by neurologic criteria for all mechanically ventilated patients regardless of organ donation potential. This Guideline is endorsed by the Canadian Critical Care Society, the Canadian Medical Association, the Canadian Association of Critical Care Nurses, Canadian Anesthesiologists{\textquoteright} Society, the Canadian Neurological Sciences Federation (representing the Canadian Neurological Society, Canadian Neurosurgical Society, Canadian Society of Clinical Neurophysiologists, Canadian Association of Child Neurology, Canadian Society of Neuroradiology, and Canadian Stroke Consortium), Canadian Blood Services, the Canadian Donation and Transplantation Research Program, the Canadian Association of Emergency Physicians, the Nurse Practitioners Association of Canada, and the Canadian Cardiovascular Critical Care Society.",

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author = "Shemie, {Sam D.} and Wilson, {Lindsay C.} and Laura Hornby and John Basmaji and Baker, {Andrew J.} and Bensimon, {C{\'e}cile M.} and Chandler, {Jennifer A.} and Micha{\"e}l Chass{\'e} and Rosanne Dawson and Sonny Dhanani and Mooney, {Owen T.} and Sarti, {Aimee J.} and Christy Simpson and Jeanne Teitelbaum and Sylvia Torrance and Boyd, {J. Gordon} and Joanne Brennan and Heather Brewster and Robert Carignan and Dawe, {Kirk J.} and Doig, {Christopher J.} and Kennedy Elliott-Pohl and Gofton, {Teneille E.} and Michael Hartwick and Andrew Healey and Kimia Honarmand and Karen Hornby and George Isac and Aly Kanji and Joann Kawchuk and Klowak, {Jennifer A.} and Kramer, {Andreas H.} and Julie Kromm and LeBlanc, {Allana E.} and Katarina Lee-Ameduri and Lee, {Laurie A.} and Murdoch Leeies and Ariane Lewis and Alex Manara and Shauna Matheson and McKinnon, {Nicole K.A.} and Nicholas Murphy and Briard, {Joel Neves} and Pope, {Thaddeus M.} and Sekhon, {Mypinder S.} and Shanker, {Jai Jai S.} and Gurmeet Singh and Jeffrey Singh and Marat Slessarev and Karim Soliman and Stephanie Sutherland and Weiss, {Matthew J.} and Shaul, {Randi Zlotnik} and Zuckier, {Lionel S.} and Zorko, {David J.} and Bram Rochwerg",

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AU - Bensimon, Cécile M.

AU - Chandler, Jennifer A.

AU - Chassé, Michaël

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AU - Isac, George

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A brain-based definition of death and criteria for its determination after arrest of circulation or neurologic function in Canada: a 2023 clinical practice guideline

Abstract

Keywords

ASJC Scopus subject areas

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