A Basis for Fluoropyrimidine-Induced Antagonism to Methotrexate in Ehrlich Ascites Tumor Cells in Vitro

Donnell Bowen; J. Courtl; I. David Goldman

A Basis for Fluoropyrimidine-Induced Antagonism to Methotrexate in Ehrlich Ascites Tumor Cells in Vitro

Donnell Bowen, J. Courtl, I. David Goldman

Research output: Contribution to journal › Article › peer-review

Abstract

The inhibitory effect of methotrexate on [3 H]deoxyuridine incorporation into DNA is reduced as the basal rate of this reaction is inhibited by pretreatment of Ehrlich ascites tumor cells with fluoropyrimidines. This observation is a basis for fluoropyrimidine-methotrexate antagonism in anticancer regimens and supports the concept that the sensitivity of thymidylate synthesis in tumor cells to methotrexate is related, in part, to the basal rate of thymidylate synthesis from deoxyuridylate.

Original language	English (US)
Pages (from-to)	219-222
Number of pages	4
Journal	Cancer research
Volume	38
Issue number	1
State	Published - Jan 1978
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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abstract = "The inhibitory effect of methotrexate on [3 H]deoxyuridine incorporation into DNA is reduced as the basal rate of this reaction is inhibited by pretreatment of Ehrlich ascites tumor cells with fluoropyrimidines. This observation is a basis for fluoropyrimidine-methotrexate antagonism in anticancer regimens and supports the concept that the sensitivity of thymidylate synthesis in tumor cells to methotrexate is related, in part, to the basal rate of thymidylate synthesis from deoxyuridylate.",

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N2 - The inhibitory effect of methotrexate on [3 H]deoxyuridine incorporation into DNA is reduced as the basal rate of this reaction is inhibited by pretreatment of Ehrlich ascites tumor cells with fluoropyrimidines. This observation is a basis for fluoropyrimidine-methotrexate antagonism in anticancer regimens and supports the concept that the sensitivity of thymidylate synthesis in tumor cells to methotrexate is related, in part, to the basal rate of thymidylate synthesis from deoxyuridylate.

AB - The inhibitory effect of methotrexate on [3 H]deoxyuridine incorporation into DNA is reduced as the basal rate of this reaction is inhibited by pretreatment of Ehrlich ascites tumor cells with fluoropyrimidines. This observation is a basis for fluoropyrimidine-methotrexate antagonism in anticancer regimens and supports the concept that the sensitivity of thymidylate synthesis in tumor cells to methotrexate is related, in part, to the basal rate of thymidylate synthesis from deoxyuridylate.

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A Basis for Fluoropyrimidine-Induced Antagonism to Methotrexate in Ehrlich Ascites Tumor Cells in Vitro

Abstract

ASJC Scopus subject areas

UN SDGs

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