6. Somatic DNA alterations and aging

Research output: Contribution to journalArticlepeer-review


Aging can be defined as a series of time-related processes occurring in the adult individual that ultimately bring life to a close. To some extent, these processes can be understood as the coordinated action of the products of multiple genes. However, aging also has a major stochastic component. Random DNA alterations, induced by both environmental and endogenous mutagens and carcinogens fall into this category and have been considered as a most likely primary cause of aging. While the age-related accumulation of DNA damage and mutations has now been amply demonstrated in various organisms, the functional relationship of this accumulation with the aging phenotype remains unclear.

Original languageEnglish (US)
Pages (from-to)95-115
Number of pages21
JournalFacts, Research and Intervention in Geriatrics
Issue numberPART 1
StatePublished - Dec 1 2000
Externally publishedYes

ASJC Scopus subject areas

  • Geriatrics and Gerontology


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