4-month-old girl with diffuse, varied dermatitis and bullae

Sarah Fuchs, Alissa Baker, Lucinda S. Liu, Brea Prindaville, Richard J. Antaya

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


• Pediatric autoimmune blistering disorders are exceedingly rare. Of these, childhood bullous pemphigoid (CBP) is the most common IgG-mediated subepidermal bullous disease in the pediatric population. Tense acral blisters, especially on the soles and palms, are characteristic of the infantile presentation. • Patients with CBP present with varied dermatoses, making clinical diagnosis alone difficult. • Definitive diagnosis is made with direct immunofluorescence revealing linear deposition of IgG and/or C3 at the basement membrane zone (BMZ) or indirect immunofluorescence revealing IgG antibodies reacting with the BMZ. • First-line treatment is oral prednisolone dosed at 1 to 2 mg/kg and then tapered slowly to avoid rebound disease. The length of treatment depends on the rate of remission.

Original languageEnglish (US)
Pages (from-to)e41-e44
JournalPediatrics in review
Issue number8
StatePublished - Aug 2014
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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