TY - JOUR
T1 - 3D-printed automation for optimized PET radiochemistry
AU - Amor-Coarasa, Alejandro
AU - Kelly, James M.
AU - Babich, John W.
N1 - Funding Information:
This work was funded in part by the Clinical and Translational Science Center at Weill Cornell Medicine through a Cooperative Agreement awarded by the National Center for Advancing Translational Sciences (grant no. 5 UL1 TR000457-07).
Publisher Copyright:
Copyright © 2019 The Authors,
PY - 2019/9/13
Y1 - 2019/9/13
N2 - Reproducible batch synthesis of radioligands for imaging by positron emission tomography (PET) in a manner that maximizes ligand yield, purity, and molar activity, and minimizes cost and exposure to radiation, remains a challenge, as new and synthetically complex radioligands become available. Commercially available automated synthesis units (ASUs) solve many of these challenges but are costly to install and cannot always accommodate diverse chemistries. Through a reiterative design process, we exploit the proliferation of three-dimensional (3D) printing technologies to translate optimized reaction conditions into ASUs composed of 3D-printed, electronic, and robotic parts. Our units are portable and robust and reduce radiation exposure, shorten synthesis time, and improve the yield of the final radiopharmaceutical for a fraction of the cost of a commercial ASU. These 3D-printed ASUs highlight the gains that can be made by designing a fit-for-purpose ASU to accommodate a synthesis over accommodating a synthesis to an unfit ASU.
AB - Reproducible batch synthesis of radioligands for imaging by positron emission tomography (PET) in a manner that maximizes ligand yield, purity, and molar activity, and minimizes cost and exposure to radiation, remains a challenge, as new and synthetically complex radioligands become available. Commercially available automated synthesis units (ASUs) solve many of these challenges but are costly to install and cannot always accommodate diverse chemistries. Through a reiterative design process, we exploit the proliferation of three-dimensional (3D) printing technologies to translate optimized reaction conditions into ASUs composed of 3D-printed, electronic, and robotic parts. Our units are portable and robust and reduce radiation exposure, shorten synthesis time, and improve the yield of the final radiopharmaceutical for a fraction of the cost of a commercial ASU. These 3D-printed ASUs highlight the gains that can be made by designing a fit-for-purpose ASU to accommodate a synthesis over accommodating a synthesis to an unfit ASU.
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U2 - 10.1126/sciadv.aax4762
DO - 10.1126/sciadv.aax4762
M3 - Article
C2 - 31548988
AN - SCOPUS:85072240807
SN - 2375-2548
VL - 5
JO - Science Advances
JF - Science Advances
IS - 9
M1 - eaax4762
ER -