3-nitropropionic acid as a tool to study the mechanisms involved in huntington's disease: Past, present and future

Isaac Túnez; Inmaculada Tasset; Verónica Pérez De La Cruz; Abel Santamaría

doi:10.3390/molecules15020878

3-nitropropionic acid as a tool to study the mechanisms involved in huntington's disease: Past, present and future

Isaac Túnez, Inmaculada Tasset, Verónica Pérez De La Cruz, Abel Santamaría

Research output: Contribution to journal › Article › peer-review

161 Scopus citations

Abstract

Huntington's disease (HD) is an inheritable autosomal-dominant disorder whose causal mechanisms remain unknown. Experimental models have begun to uncover these pathways, thus helping to understand the mechanisms implicated and allowing for the characterization of potential targets for new therapeutic strategies. 3-Nitropropionic acid is known to produce in animals behavioural, biochemical and morphologic changes similar to those occurring in HD. For this reason, this phenotypic model is gaining attention as a valuable tool to mimick this disorder and further developing new therapies. In this review, we will focus on the past and present research of this molecule, to finally bring a perspective on what will be next in this promising field of study.

Original language	English (US)
Pages (from-to)	878-916
Number of pages	39
Journal	Molecules
Volume	15
Issue number	2
DOIs	https://doi.org/10.3390/molecules15020878
State	Published - Feb 2010
Externally published	Yes

Keywords

3-nitropropionic acid
Huntington's disease
Quinolinic acid
Succinate dehydrogenase
Transgenic mice models

ASJC Scopus subject areas

Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry

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10.3390/molecules15020878

Cite this

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abstract = "Huntington's disease (HD) is an inheritable autosomal-dominant disorder whose causal mechanisms remain unknown. Experimental models have begun to uncover these pathways, thus helping to understand the mechanisms implicated and allowing for the characterization of potential targets for new therapeutic strategies. 3-Nitropropionic acid is known to produce in animals behavioural, biochemical and morphologic changes similar to those occurring in HD. For this reason, this phenotypic model is gaining attention as a valuable tool to mimick this disorder and further developing new therapies. In this review, we will focus on the past and present research of this molecule, to finally bring a perspective on what will be next in this promising field of study.",

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AU - Santamaría, Abel

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3-nitropropionic acid as a tool to study the mechanisms involved in huntington's disease: Past, present and future

Abstract

Keywords

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